Antonio Piñero-Madrona

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BACKGROUND Tumour suppressor genes are often transcriptionally silenced by promoter hypermethylation, and recent research has implicated alterations in chromatin structure as the mechanistic basis for this repression. In addition to DNA methylation, other epigenetic post-translational modifications that modulate the stability and binding of specific(More)
Sir, A recent work remarks the influence of molecular lymph node assay to diagnose micrometastases in the sentinel node of intraductal carcinoma of the breast (Osako et al, 2012). In fact, the detection of small epithelial cell aggregates became much more frequent as the sentinel lymph node biopsy replaced complete axillary dissection as a method of staging(More)
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