BACKGROUND Atrazine, one of the most common pesticide contaminants, has been shown to up-regulate aromatase activity in certain estrogen-sensitive tumors without binding or activating the estrogen receptor (ER). Recent investigations have demonstrated that the orphan G-protein-coupled receptor 30 (GPR30), which is structurally unrelated to the ER, mediates… (More)
BACKGROUND The pesticide atrazine does not bind to or activate the classical estrogen receptor (ER), but it up-regulates the aromatase activity in estrogen-sensitive tumor cells. The G protein estrogen receptor (GPR30/GPER) has been reported to be involved in certain biological responses to endogenous estrogens and environmental compounds exerting… (More)
" On ne trouvera point de Figures dans cet Ouvrage. Les méthodes que j'y expose ne demandent ni constructions, ni raisonnemens géométriques ou méchaniques, mais seulement des opérations algébriques, assujetties à une marche réguliere et uniforme. Ceux qui aiment l'Analyse, verront avec plaisir la Méchanique en divenir une nouvelle branche, et me sauront gré… (More)
In this paper a general set of equations of motion and duality conditions to be imposed at macroscopic surfaces of discontinuity in partially saturated, solid-second gradient porous media are derived by means of the Least Action Principle. The need of using a second gradient (of solid displacement) theory is shown to be necessary to include in the model… (More)
The isolation of the G-protein-coupled receptor 30 (GPR30), an orphan membrane receptor unrelated to nuclear estrogen receptors (ERs), has become a key factor towards the unraveling of rapid estrogen action. This membrane receptor together with cellular signaling intermediaries, i.e., extracellular signal-dependent kinases 1 and 2, may promote neuronal… (More)
MRI and ultrasound versus conventional measures of disease activity and structural damage in evaluating treatment efficacy in JIA. Do these imaging techniques have an additional value?