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BACKGROUND Neurons require highly specialized intracellular membrane trafficking, especially at synapses. Rab GTPases are considered master regulators of membrane trafficking in all cells, and only very few Rabs have known neuron-specific functions. Here, we present the first systematic characterization of neuronal expression, subcellular localization, and(More)
Wearable accelerometry provides easily portable systems that supply real-time data adequate for gait analysis. When they do not provide direct measurement of a spatio-temporal parameter of interest, such as step length, it has to be estimated with a mathematical model from indirect sensor measurements. In this work we are concerned with the(More)
  • Marcel Leutenegger, Erica Martin-Williams, Pascal Harbi, Tyler Thacher, Wassim Raffoul, Marc André +3 others
  • 2011
We present a full field laser Doppler imaging instrument, which enables real-time in vivo assessment of blood flow in dermal tissue and skin. This instrument monitors the blood perfusion in an area of about 50 cm(2) with 480 × 480 pixels per frame at a rate of 12-14 frames per second. Smaller frames can be monitored at much higher frame rates. We recorded(More)
This paper presents new significant advances in the Disciple approach for building knowledge-based systems by subject matter experts. It describes the innovative application of this approach to the development of an agent for the analysis of strategic centers of gravity in military conflicts. This application has been deployed in several courses at the US(More)
BACKGROUND Aging is associated with a decrease in physical skills, sometimes accompanied by a change in quality of life (QOL). Long-term martial arts practice has been proposed as an avenue to counter these deleterious effects. The general purpose of this pilot study was to identify the effects of an adapted karate training program on QOL, depression, and(More)
In the present study the prognostic value of both DNA ploidy and the proliferative activity of tumour cells were studied in a series of 76 consecutive patients suffering from gastric tumours. DNA ploidy and the proliferative index (as measured by the percentage of S-phase cells) were determined by flow cytometry using fresh tumour specimens. The presence of(More)
  • Raniero L Peru Y Colón de Portugal, Shamsideen A Ojelade, Pranav S Penninti, Rachel J Dove, Matthew J Nye, Summer F Acevedo +3 others
  • 2014
To understand the molecular and neural mechanisms underlying alcohol addiction, many models ranging from vertebrates to invertebrates have been developed. In Drosophila melanogaster, behavioral paradigms from assaying acute responses to alcohol and to behaviors more closely modeling addiction have emerged in recent years. However, both the CAFÉ assay,(More)
– Pedestrian detection has gained a lot of prominence during the last few years. Besides the fact that it is one of the hardest tasks within computer vision, it involves huge computational costs. Obtaining acceptable real-time performance, measured in frames per second (fps), for the most advanced algorithms is nowadays a hard challenge. In this work, we(More)
The identification of a beta-cell tracer is a major quest in diabetes research. However, since MRI, PET and SPECT cannot resolve individual islets, optical techniques are required to assess the specificity of these tracers. We propose to combine Optical Coherence Microscopy (OCM) with fluorescence detection in a single optical platform to facilitate these(More)