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A copper(I)-mediated one-pot synthesis of 2,3-dihydro-1H-indazole heterocycles has been developed. This synthetic route provides the desired indazoles in moderate to good yields (55%-72%) which are substantially better than those achievable with an alternative two-step reaction sequence. The reaction is tolerant of functionality on the aromatic ring.
Graphical techniques are recommended for critical applications because they allow for visual analysis and helpful understanding of the results, also for non-statisticians. However, “graphical” estimation methods are often criticized because they are less efficient with respect to “analytical” methods. This paper proposes a new general graphical method that… (More)
A titanocene-catalyzed multicomponent coupling is described herein. Using catalytic titanocene, phosphine, and zinc dust, zinc acetylides can be generated from the corresponding iodoalkynes to affect sequential nucleophilic additions to aromatic aldehydes. The intermediate propargylic alkoxides are trapped in situ with acetic anhydride, which are… (More)