Antonio L’Abbate

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Insulin resistance (IR) and endothelial dysfunction are frequently associated in cardiac disease. The T−786→C variant in the promoter region of the endothelial nitric oxide synthase (eNOS) gene has been associated with IR in both non-diabetic and diabetic subjects. Aim of the study was to assess the reciprocal relationships between T−786→C eNOS polymorphism(More)
Voluntary breath holding represents a physiological model of hypoxia. It consists of two phases of oxygen saturation dynamics: an initial slow decrease (normoxic phase) followed by a rapid drop (hypoxic phase) during which transitory neurological symptoms as well as slight impairment of integrated cerebral functions, such as emotional processing, can occur.(More)
Up-regulation of HO-1 by genetic manipulation or pharmacological pre-treatment has been reported to provide benefits in several animal models of myocardial infarction (MI). However, its efficacy following MI initiation (as in clinical reality) remains to be tested. Therefore, this study investigated whether HO-1 over-expression, by cobalt protoporphyrin(More)
Myocardial dysfunction and coronary macro/microvascular alterations are the hallmarks of diabetic cardiomyopathy and are ascribed to increased oxidative stress and altered nitric oxide synthase (NOS) activity. We hypothesize that pre-treatment by cobalt-protoporphyrin IX (CoPP) ameliorates both myocardial function and coronary circulation in streptozotocin(More)
Abnormalities in eNOS gene, possibly interacting with high fat diet (HFD), affect peripheral vascular function and glucose metabolism. The relative role of eNOS gene, HFD and metabolic derangement on coronary function has not been fully elucidated. We test whether eNOS gene deficiency per se or in association with HFD modulates coronary function through(More)
Obesity-associated inflammation causes insulin resistance. Obese adipose tissue displays hypertrophied adipocytes and increased expression of the cannabinoid-1 receptor. Cobalt protoporphyrin (CoPP) increases heme oxygenase-1 (HO-1) activity, increasing adiponectin and reducing inflammatory cytokines. We hypothesize that CoPP administration to Zucker(More)
Cardiac changes induced by immersion and breath-hold diving in humans. evaluate the separate cardiovascular response to body immersion and increased environmental pressure during diving, 12 healthy male subjects (mean age 35.2 Ϯ 6.5 yr) underwent two-dimensional Doppler echocardiog-raphy in five different conditions: out of water (basal); head-out immersion(More)
Danilo Neglia, Alberto De Caterina, Paolo Marraccini, Andrea Natali, Marco Ciardetti, Cecilia Vecoli, Amalia Gastaldelli, Demetrio Ciociaro, Paola Pellegrini, Roberto Testa, Luca Menichetti, Antonio L’Abbate, William C. Stanley, and Fabio A. Recchia Institute of Clinical Physiology, National Council for Research; Department of Medicine, University of Pisa;(More)
Time-correlated single photon counting (TCSPC) is popular in the resolved techniques due to its prominent performance such as ultra-high time resolution and ultra-high sensitivity. This paper presents advance signal processing techniques on the optical TCSPC signals obtained from the series of experiments on fabricated tissue like phantom. A pulsed laser(More)
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