Antonio Guzman

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BACKGROUND The Consortium to Investigate Vascular Impairment of Cognition (CIVIC) is a Canadian, multi-centre, clinic-based prospective cohort study of patients with Vascular Cognitive Impairment (VCI). We report its organization and the impact of diagnostic criteria on the study of VCI. METHODS Nine memory disability clinics enrolled patients and(More)
UNLABELLED Gamma aminobutyric acid (GABA)A receptor modulators constitute the majority of clinically used sedative-hypnotics. These compounds have the capacity to initiate and maintain sleep, but decrease REM sleep and delta activity within NREM sleep. In order to avoid such sleep adverse effects, the development of novel compounds remains of interest. (More)
Intracellular recordings were made from fetal mouse spinal cord neurons in primary culture. One type of neuron, with large somata (40-50 microns diameter) and thick neurites exhibited endogenous bursting or beating pacemaker electrical activity. Noradrenaline depolarized this type of neuron by decreasing an M-like conductance. Micropressure application of(More)
BACKGROUND AND PURPOSE Empirical studies to clarify the outcomes in Vascular Cognitive Impairment (VCI) are needed. We compared cognitive, functional, and behavioural outcomes in patients with VCI to patients with no cognitive impairment (NCI), and Alzheimer's disease (AD). METHODS Secondary analysis of the Consortium to Investigate Vascular Impairment of(More)
BACKGROUND AND PURPOSE There is a need for empirical studies to define criteria for vascular cognitive impairment (VCI) subtypes. In this paper, we report the predictive validity of a subtype classification scheme based on clinical and radiographic features. METHODS Nine Canadian memory clinics participated in the Consortium to Investigate Vascular(More)
Intracellular recordings were made from dissociated fetal mouse spinal cord neurones in primary culture. Micropressure application of FLFQPQRFamide (10(-5) M in the delivery pipette), an endogenous mammalian brain morphine modulating peptide, onto the surface of spinal cord neurones induced, in a dose dependent manner, a transitory hyperpolarization(More)
The growth of self-assembled quantum dots has been intensively studied in the last decade. Despite substantial efforts, a number of details of the growth process remain unknown. The reason is the inability of current characterization techniques to image the growth process in real time. In this work, this limitation is alleviated by the use of kinetic Monte(More)
A Spanish translation of the Diagnostic Interview Schedule (DIS) was assessed using samples of Puerto Rican patients and community subjects from the San Juan area. Concordance between DIS results from psychiatrists' interviews and from laypersons' interviews was similar to results with the DIS in mainland samples. Comparisons of laypersons' DIS results with(More)
New atomic transition probability measurements for 948 lines of Ti i are reported. Branching fractions from Fourier transform spectra and from spectra recorded using a 3 m echelle spectrometer are combined with published radiative lifetimes from laser-induced fluorescence measurements to determine these transition probabilities. Generally good agreement is(More)
quantity of sleep. Insomniacs may present with one or more symptoms including difficulties in initiating and maintaining sleep, frequent nocturnal arousals or early morning awakening with inability to get back to sleep, and non-restorative sleep. Gamma amino butyric acid (GABA) A receptor modulators such as zolpidem and zopiclone are the most widely(More)
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