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Therapies that target the programmed death-1 (PD-1) receptor have shown unprecedented rates of durable clinical responses in patients with various cancer types. One mechanism by which cancer tissues limit the host immune response is via upregulation of PD-1 ligand (PD-L1) and its ligation to PD-1 on antigen-specific CD8(+) T cells (termed adaptive immune(More)
The European Space Agency mission SMOS was successfully launched on November 2nd, 2009. Its main objectives are the determination of Soil Moisture over land [1] and Sea Surface Salinity over the oceans [2], with an accuracy of 0.04 m3/m3 every 3 days with a spatial resolution of 50 km [3, R-4.6.1-002 to 004] at level 2, and 0.1 psu every 10 days with a(More)
—The SMOS data product steps from raw data to brightness temperature maps are described. Originally ordered in the sequence of snapshots, the data are rearranged for the Level 1c Brightness Temperature maps according to their location in a Discrete Global Grid (DGG). A number of candidate DGGs are introduced and their suitability is evaluated
The xCELLigence system is a new technological approach that allows the real-time cell analysis of adherent tumor cells. To date, xCELLigence has not been able to monitor the growth or cytotoxicity of nonadherent cells derived from hematological malignancies. The basis of its technology relies on the use of culture plates with gold microelectrodes located in(More)
The therapeutic effect of doxorubicin (DXR) in the treatment of soft tissue sarcomas (STS) is limited by its toxicity and the development of multidrug resistance (MDR), the latter mainly induced by high expression of efflux pumps (e.g., P-glycoprotein [P-gp]). Therefore, the search for alternative therapies, which sensitize these tumors to chemotherapy(More)
Minerval is an oleic acid synthetic analogue that impairs lung cancer (A549) cell proliferation upon modulation of the plasma membrane lipid structure and subsequent regulation of protein kinase C localization and activity. However, this mechanism does not fully explain the regression of tumours induced by this drug in animal models of cancer. Here we show(More)
The European Space Agency (ESA) successfully launched the Soil Moisture and Ocean Salinity (SMOS) mission in November 2, 2009. SMOS uses a new type of instrument, a synthetic aperture radiometer named MIRAS that provides full-polarimetric multi-angular L-band brightness temperatures, from which regular and global maps of Sea Surface Salinity (SSS) and Soil(More)