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The term livedo reticularis refers to a reddish-violet reticular discoloration of the skin that mainly affects the limbs. It is caused by an interruption of blood flow in the dermal arteries, either due to spasm, inflammation, or vascular obstruction, and is associated with diseases of varying etiology and severity. To establish the cause of livedo(More)
The expansion of genetic, genomic, environmental and metabolic knowledge that contributes to the immunological dysregulation in lupus is extremely challenging to those attempting to establish a 'gold standard' classification of systemic lupus erythematosus (SLE). 1 An approach that incorporates this information into its classification may help in attaining(More)
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