Antonio Alcamí

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Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species soecificity

Julian A. Symons, Antonio Alcamí, Geoffrey L Smith
Cell
1995

Vaccinia virus (VV) and other orthopoxviruses express a soluble type I interferon (IFN) receptor that for VV strain Western Reserve is encoded by gene B18R. The 60-65 kDa glycoprotein is related to… (More)

A soluble receptor for interleukin-1β encoded by vaccinia virus: A novel mechanism of virus modulation of the host response to infection

Vaccinia virus gene B15R is shown to encode an abundant, secretory glycoprotein that functions as a soluble interleukin-1 (IL-1) receptor. This IL-1 receptor has novel specificity since, in contrast… (More)

Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon receptors with novel broad species specificity.

Antonio Alcamí, Geoffrey L Smith
Journal of virology
1995

Soluble receptors for gamma interferon (IFN-gamma) are secreted from cells infected by 17 orthopoxviruses, including vaccinia, cowpox, rabbitpox, buffalopox, elephantpox, and camelpox viruses,… (More)

Viral mimicry of cytokines, chemokines and their receptors

Antonio Alcamí
Nature Reviews Immunology
2003

Viruses have evolved elegant mechanisms to evade detection and destruction by the host immune system. One of the evasion strategies that have been adopted by large DNA viruses is to encode homologues… (More)

Blockade of chemokine activity by a soluble chemokine binding protein from vaccinia virus.

Antonio Alcamí, Julian A. Symons, P D Collins, Timothy J. Williams, Geoffrey L Smith
Journal of immunology
1998

Chemokines direct migration of immune cells into sites of inflammation and infection. Chemokine receptors are seven-transmembrane domain proteins that, in contrast to other cytokine receptors, cannot… (More)

The vaccinia virus soluble alpha/beta interferon (IFN) receptor binds to the cell surface and protects cells from the antiviral effects of IFN.

Antonio Alcamí, Julian A. Symons, Geoffrey L Smith
Journal of virology
2000

Poxviruses encode a broad range of proteins that interfere with host immune functions, such as soluble versions of receptors for the cytokines tumor necrosis factor, interleukin-1 beta, gamma… (More)

A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus.

Alí Alejo, Maria Begoña Ruiz-Argüello, Yin Wan Ho, Vincent P. Smith, M. Saraiva, Antonio Alcamí
Proceedings of the National Academy of Sciences…
2006

Variola virus (VaV) is the causative agent of smallpox, one of the most devastating diseases encountered by man, that was eradicated in 1980. The deliberate release of VaV would have catastrophic… (More)

A Broad Spectrum Secreted Chemokine Binding Protein Encoded by a Herpesvirus

Christopher M. Parry, J Pedro Simas, +4 authors Antonio Alcamí
The Journal of experimental medicine
2000

Chemokines are a family of small proteins that interact with seven-transmembrane domain receptors and modulate the migration of immune cells into sites of inflammation and infection. The murine… (More)

Vaccinia virus strains Lister, USSR and Evans express soluble and cell-surface tumour necrosis factor receptors.

Antonio Alcamí, Anu Khanna, Nina Paul, Geoffrey L Smith
The Journal of general virology
1999

Poxviruses encode a broad range of proteins that interfere with host immune functions such as soluble versions of cytokine receptors. Soluble virus tumour necrosis factor receptors (vTNFRs) were… (More)

The UL144 gene product of human cytomegalovirus activates NFkappaB via a TRAF6-dependent mechanism.

Emma L. Poole, Christine A King, John H. Sinclair, Antonio Alcamí
The EMBO journal
2006

Molecular mimicry of cytokines and cytokine receptors is a strategy used by poxviruses and herpesviruses to modulate host immunity. The human cytomegalovirus (HCMV) UL144 gene, situated in the UL/b'… (More)

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