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The neuropeptide orphanin FQ (also known as nociceptin; OFQ/N) has been implicated in modulating stress-related behavior. OFQ/N was demonstrated to reverse stress-induced analgesia and possess anxiolytic-like activity after central administration. To further study physiological functions of OFQ/N, we have generated OFQ/N-deficient mice by targeted(More)
We have used site-directed mutagenesis in conjunction with homologous recombination to generate two mouse lines carrying point mutations in the glycine binding site of the NMDAR1 subunit (Grin1). Glycine concentration-response curves from acutely dissociated hippocampal neurons revealed a 5- and 86-fold reduction in receptor glycine affinity in mice(More)
The GluR2 subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptor determines many of the biophysical properties of native AMPA receptors, including Ca++ permeability. Genetically engineered mice unable to edit the Q to R site of the GluR2 subunit die within 3 wk postpartum, presumably due to toxicity associated with enhanced(More)
The adoption of mobile commerce in service industries is lacking behind expectations. One reason is the missing trust of consumers in mobile devices as a shopping platform. We investigated the impact of three types of recommender systems on consumers' trusting beliefs and purchase intention by varying the level of social presence in recommender systems.(More)
Mobile Endgeräte stellen Funktionen bereit, die es Unternehmen ermöglichen, ihren Kunden passgenaue, standortspezifische Dienstleistungen anzubieten. Im Vergleich zum klassischen Onlinehandel oder zu Einkäufen in Ladengeschäften werden Vertragsabschlüsse über mobile Endgeräte von den Konsumenten jedoch weiterhin als riskanter wahrgenommen.(More)
The advancement of communication tools has changed interpersonal communication among consumers. Companies leverage different communication tools to reach customers, while it is unclear, how communication types affect online referral acceptance. This study draws on affordances and social presence theory to investigate the role of two communication types(More)
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