Antonia Chatzopoulou

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In humans and zebrafish, 2 glucocorticoid (GC) receptor (GR) splice variants exist: the canonical GR α-isoform (GRα), and the GRβ. In the present study, we have used the zebrafish model system in order to reveal genes affected by each of these 2 receptor isoforms. By injecting zebrafish embryos with different splice-blocking morpholinos, we could knock down(More)
Glucocorticoids regulate a wide range of systems in vertebrate organisms, and their effects are mediated by the glucocorticoid receptor (GR). The responsiveness to glucocorticoids differs largely between individuals. Resistance to glucocorticoids is an important medical problem, since it limits the efficacy of glucocorticoids when they are used to treat(More)
Glucocorticoids regulate a plethora of physiological processes, and are widely used clinically as anti-inflammatory drugs. Their effects are mediated by the glucocorticoid receptor (GR), a ligand-activated transcription factor. Currently, zebrafish embryos are being developed into a model system for GR research, since they are easy to manipulate genetically(More)
Homecare telematics can be regarded as one of the fastest growing healthcare delivery sectors in the developed world and it is further reinforced as healthcare delivery paradigm is shifting from doctor and hospital-centered towards a new model where the citizen becomes responsible for the personalized management of healthcare, delivered at the point of(More)
An important issue in the advancement and deployment of home care telematic services is their assessment, especially with the goal of improving such services and making them easier to integrate into the social and clinical setting. The meaning that researchers apply to assistive environments and telehealth in general, (i.e. a medical innovation or a drug(More)
Glucocorticoids are steroid hormones that are secreted upon stress. Their effects are mediated by the glucocorticoid receptor, which acts as a transcription factor. Because the antiinflammatory activity of glucocorticoids has been well established, they are widely used clinically to treat many inflammatory and immune-related diseases. However, the exact(More)
In humans, two splice variants of the glucocorticoid receptor (GR) exist: the canonical α-isoform, and the β-isoform, which has been shown to have a dominant-negative effect on hGRα. Previously, we have established the occurrence of a GR β-isoform in zebrafish, and in the present study we have investigated the functional role of the zebrafish GRβ (zGRβ).(More)
An important issue in the advancement and deployment of home care telematic services is their assessment, especially with the goal to improve such services and constitute them easier to integrate into the social and clinical setting. The meaning that researchers apply to assistive environments and telehealth in general (i.e. a medical innovation or a drug(More)
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