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OBJECTIVES High levels of soluble receptor for advanced glycation end products (sRAGE) have been shown to have an atheroprotective role; however, no data are available on this molecule in acute coronary syndromes (ACS). We evaluated sRAGE levels in patients with non-ST segment elevation ACS (NSTE-ACS) or with chronic stable angina. METHODS We studied 265(More)
Brain- derived neurotrophic factor (BDNF) is linked to neurodegenerative diseases (e.g. Alzheimer disease and Parkinson disease) which are often characterized by olfactory impairment. A specific single nucleotide polymorphism of the BDNF gene, the Val66Met, modulates intracellular trafficking and activity-dependent secretion of BDNF protein. The aim of this(More)
BACKGROUND AND AIM The effects of tibolone on cardiovascular risk is not yet fully understood today. We designed this study to assess the effect of the menopausal status and tibolone treatment (2.5 mg/day for 3 months) on different biomarkers of cardiovascular risk in healthy women. METHODS Blood arterial pressure were measured, and blood samples(More)
Prospective studies that incorporate both gene testing and a variety of ethnic, clinical, pharmacological, and environmental variables, along with age, sex, and body weight, will be required to demonstrate the real safety, cost-effectiveness, and feasibility of individualized dosing regimens according to the statistical models for warfarin dose calculation.(More)
UNLABELLED Oxidative stress plays a key role in the pathogenesis and development of atherosclerosis. AIM To evaluate the relationship between a novel oxidative stress index (reflecting both oxidative and anti-oxidant counterparts) with traditional cardiovascular risk factors and C-reactive protein (CRP) in coronary artery disease (CAD). METHODS 100(More)
OBJECTIVE To assess oxidative stress status in coronary artery disease (CAD) patients according to gender. DESIGN Case-controlled, observational, retrospective study. SETTING Clinical and research center. PATIENT(S) A total of 55 postmenopausal women and 108 men (mean age: 66 ± 9 years), including 72 patients with angiographically proven CAD (CAD(+),(More)
OBJECTIVE To evaluate whether obesity and smoking habit may accelerate the age-related increase of oxidative stress. METHODS The Oxidative-INDEX, a score reflecting both oxidative and antioxidant counterparts, was estimated in 179 subjects (50 males, aged 16-79 years). RESULTS Oxidative stress results were elevated in obese and smoker subjects. Adjusted(More)
AIM Genome-wide association studies have identified single-nucleotide polymorphisms at the 10q11 locus as risk factors for myocardial infarction (MI). This locus lies upstream (∼80 kb) of the stromal cell-derived factor-1 (SDF1) gene that codify for a chemokine with protective atherogenetic effects and with a major role in the mobilization, homing, and(More)
Telomere shortening is considered a cellular marker of health status and biological ageing. Exercise may influence the health and lifespan of an individual by affecting telomere length (TL). However, it is unclear whether different endurance exercise levels may have beneficial or detrimental effects on biological aging. The aims of the study were to assess(More)
BACKGROUND Magnitude and major causes of oxidative stress may be different between sexes, although limitedly addressed in clinical studies with controversial results. The present study aimed to determine whether any gender-related difference exists concerning oxidative stress in a population of 332 subjects of both sexes, in a wide age range, with and(More)