Antonella Mercuri

Learn More
UNLABELLED Oxidative stress plays a key role in the pathogenesis and development of atherosclerosis. AIM To evaluate the relationship between a novel oxidative stress index (reflecting both oxidative and anti-oxidant counterparts) with traditional cardiovascular risk factors and C-reactive protein (CRP) in coronary artery disease (CAD). METHODS 100(More)
OBJECTIVES High levels of soluble receptor for advanced glycation end products (sRAGE) have been shown to have an atheroprotective role; however, no data are available on this molecule in acute coronary syndromes (ACS). We evaluated sRAGE levels in patients with non-ST segment elevation ACS (NSTE-ACS) or with chronic stable angina. METHODS We studied 265(More)
OBJECTIVE To assess oxidative stress status in coronary artery disease (CAD) patients according to gender. DESIGN Case-controlled, observational, retrospective study. SETTING Clinical and research center. PATIENT(S) A total of 55 postmenopausal women and 108 men (mean age: 66 ± 9 years), including 72 patients with angiographically proven CAD (CAD(+),(More)
Although cardiovascular disease (CVD) has always been perceived as a pathology regarding essentially males, incidence and death from cardiovascular events dramatically increase after menopause in women. Obviously, while many aspects of CVD are similar in both sexes, it is now clear that there are significant differences as well. Exploration of these(More)
Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, cognitive and social activities, correlate with reduced dementia risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known(More)
Brain- derived neurotrophic factor (BDNF) is linked to neurodegenerative diseases (e.g. Alzheimer disease and Parkinson disease) which are often characterized by olfactory impairment. A specific single nucleotide polymorphism of the BDNF gene, the Val66Met, modulates intracellular trafficking and activity-dependent secretion of BDNF protein. The aim of this(More)
BACKGROUND To evaluate whether the route of estrogen therapy (ET) may affect the levels of different vasoactive factors in healthy recent post-menopausal women. METHODS We conducted a cross-over study in 20 healthy nonsmoking women in recent postmenopause (1.8+/-0.1 years). Women received either 1-month oral-ET (O-ET, 2 mg oral micronized 17beta estradiol(More)
OBJECTIVE To evaluate whether obesity and smoking habit may accelerate the age-related increase of oxidative stress. METHODS The Oxidative-INDEX, a score reflecting both oxidative and antioxidant counterparts, was estimated in 179 subjects (50 males, aged 16-79 years). RESULTS Oxidative stress results were elevated in obese and smoker subjects. Adjusted(More)
BACKGROUND AND AIM The effects of tibolone on cardiovascular risk is not yet fully understood today. We designed this study to assess the effect of the menopausal status and tibolone treatment (2.5 mg/day for 3 months) on different biomarkers of cardiovascular risk in healthy women. METHODS Blood arterial pressure were measured, and blood samples(More)
Prospective studies that incorporate both gene testing and a variety of ethnic, clinical, pharmacological, and environmental variables, along with age, sex, and body weight, will be required to demonstrate the real safety, cost-effectiveness, and feasibility of individualized dosing regimens according to the statistical models for warfarin dose calculation.(More)