Antonella Malcangi

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An Acremonium chrysogenum strain improvement program based on the transformation with cephalosporin biosynthetic genes was carried out to enhance cephalosporin C production. Best results were obtained with cefEF and cefG genes, selecting transformants with increased cephalosporin C production and lower accumulation of biosynthetic intermediates. Phleomycin(More)
Teicoplanin is a new antibiotic isolated from the fermentation broth of Actinoplanes teichomyceticus nov. sp. It's a glycopeptide antibiotic belonging to the same family as vancomycin, active against Gram-positive bacteria. The antimicrobial activity of this drug was evaluated in 32 patients suffering from different infections due to Gram-positive bacteria.(More)
In this study the clinical microbiologic efficacy of a new antibiotic, Teicoplanin, has been reported. Teicoplanin was given to both male and female patients (200 or 400 mg/die doses) suffering from ORL infections. The microbial flora of the inflammatory focus was checked before and after antibiotic administration. Complete microbiologic eradication(More)
The incidence of methicillin-resistant Strains is increasing in these last years. This increase is particularly evident in Strains isolated from hospital environments. In this work we evaluated the methicillin-resistance of 58 Staphylococcus Strains, isolated from a surgical intensive care ward, in various experimental conditions, which changing in: culture(More)
A total of 1659 bacteria Strains were examined for susceptibility to different drugs by the Kirby-Bauer method. The isolates came from the General Medicine ward of Castellamonte's hospital (USSL 40). The results were retrospectively studied and statistically elaborated. The study lasted from 2 to 7 years depending on the antibiotic considered. The isolates(More)
The first report of human infections due to Campylobacter dates back to 1947. These microorganisms, classified initially as Vibrio, had been known for many years as agents of several diseases in animals. In 1963 they were grouped in the new Genus Campylobacter belonging to Spirillaceae. Campylobacter are ever more important, particularly C. jejuni, which is(More)
Aztreonam is a monobactam antibiotic active against aerobic gram-negative bacteria. The susceptibility of 127 urinary tract isolates to aztreonam, cefotaxime, cefonicid and ceftazidime was determined. Aztreonam showed good antibacterial activity even against Pseudomonas spp. Only 7 bacterial strains were resistant to aztreonam. The clinical efficacy and(More)