Antonella Malcangi

Learn More
An Acremonium chrysogenum strain improvement program based on the transformation with cephalosporin biosynthetic genes was carried out to enhance cephalosporin C production. Best results were obtained with cefEF and cefG genes, selecting transformants with increased cephalosporin C production and lower accumulation of biosynthetic intermediates. Phleomycin(More)
The first report of human infections due to Campylobacter dates back to 1947. These microorganisms, classified initially as Vibrio, had been known for many years as agents of several diseases in animals. In 1963 they were grouped in the new Genus Campylobacter belonging to Spirillaceae. Campylobacter are ever more important, particularly C. jejuni, which is(More)
Numerous studies have been carried out to specify bacterial frequencies in the urinary tract infections. In such researches the prevalence of Gram negative bacterial species has generally emerged, the most part of these ones would be Enterobatteriaceae (and among them E. coli has a special prominent position); on the other hand several Authors have often(More)
Current methods for the "in vitro" study of antibiotic activity, as minimum inhibitory concentration, expose bacteria to constant concentrations of antibiotics. The "in vivo" situation is significantly different, since the antibiotic concentration changes with time. Pharmacokinetic models are "in vitro" experimental systems that seek to simulate conditions(More)
Teicoplanin is a new antibiotic isolated from the fermentation broth of Actinoplanes teichomyceticus nov. sp. It's a glycopeptide antibiotic belonging to the same family as vancomycin, active against Gram-positive bacteria. The antimicrobial activity of this drug was evaluated in 32 patients suffering from different infections due to Gram-positive bacteria.(More)
The aim of this study was to determine the role of mezlocillin, a new acylureidopenicillin, in otorhinolaryngology. One hundred and forty-four bacterial strains were isolated from 100 patients suffering from infections of the oropharyngeal tract. Among the isolates only 10 (6.9%) resulted in being mezlocillin-resistant by the agar diffusion method. Minimum(More)