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Process mining techniques have recently received notable attention in the literature; for their ability to assist in the (re)design of complex processes by automatically discovering models that explain the events registered in some log traces provided as input. Following this line of research, the paper investigates an extension of such basic approaches,(More)
Bioinformatics is as a bridge between life science and computer science: computer algorithms are needed to face complexity of biological processes. Bioinformatics applications manage complex biological data stored into distributed and often heterogeneous databases and require large computing power. We discuss requirements of such applications and present(More)
Today's workflow management systems represent a key technological infrastructure for advanced applications that is attracting a growing body of research, mainly focused in developing tools for workflow management, that allow users both to specify the "static" aspects, like preconditions, precedences among activities, and rules for exception handling, and to(More)
Process mining techniques attempt to extract non-trivial and useful information from event logs recorded by information systems. For example, there are many process mining techniques to automatically discover a process model based on some event log. Most of these algorithms perform well on structured processes with little disturbances. However, in reality(More)
Process discovery has emerged as a powerful approach to support the analysis and the design of complex processes. It consists of analyzing a set of traces registering the sequence of tasks performed along several enactments of a transactional system, in order to build a process model that can explain all the episodes recorded over them. An approach to(More)
AKT and MAPK signaling are involved in the resistance of breast cancer cells to the EGFR tyrosine kinase inhibitor gefitinib. RAS proteins are upstream mediators that transfer messages from surface receptors to intracellular signal transducers including MAPK and AKT pathways. AZD3409 is a novel prenyl inhibitor that has shown activity against both farnesyl(More)
We propose a general framework for the process mining problem which encompasses the assumption of workflow schema with local constraints only, for it being applicable to more expressive specification languages, independently of the particular syntax adopted. In fact, we provide an effective technique for process mining based on the rather unexplored concept(More)
Process mining techniques have been receiving great attention in the literature for their ability to automatically support process (re)design. The output of these techniques is a concrete workflow schema that models all the possible execution scenarios registered in the logs, and that can be profitably used to support further-coming enactments. In this(More)
Previous mutational analysis of the L1 region of the RecA protein suggested that Gly-157 and Glu-158 are 'hot-spots' for the occurrence of constitutive LexA co-protease mutants (coprt[c]). In the present study, we clearly establish that position 157 is a hot-spot for the occurrence of such mutants, as 12 of 14 and 10 of 14 substitutions result in this(More)