Anton O. Vitovtov

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Senescence-accelerated OXYS rats are an experimental model of accelerated aging that was established from Wistar stock via selection for susceptibility to cataractogenic effects of a galactose-rich diet and via subsequent inbreeding of highly susceptible rats. Currently, we have the 102nd generation of OXYS rats with spontaneously developing cataract and(More)
Cellular and organismal aging are driven in part by the MTOR (mechanistic target of rapamycin) pathway and rapamycin extends life span inC elegans, Drosophila and mice. Herein, we investigated effects of rapamycin on brain aging in OXYS rats. Previously we found, in OXYS rats, an early development of age-associated pathological phenotypes similar to several(More)
The increasing prevalence of sarcopenia (with the gradually aging population) necessitates the development of effective prophylactic strategies. As promising geroprotectors that comprehensively influence the processes of aging, mimetics of caloric restriction are being actively studied, for example, the antidiabetic agent biguanide Metformin (MF). We tested(More)
BACKGROUND Mitochondrial dysfunction is called the missing link between brain aging and Alzheimer's disease (AD), the most common type of age-related dementia worldwide. Among the most advanced and promising of approaches to prevention or slowing of AD are therapeutic strategies targeting mitochondria. OBJECTIVE Mitochondria-targeted antioxidant SkQ1 can(More)
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