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  • Hongbo Chi, Seán P. Barry, +4 authors Richard A. Flavell
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2006 (First Publication: 6 February 2006)
  • Engagement of Toll-like receptors (TLRs) on macrophages leads to activation of the mitogen-activated protein kinases (MAPKs), which contribute to innate immune responses. MAPK activity is regulatedExpand
  • Sabrina Diano, Zhong-wu Liu, +16 authors Tamás L. Horváth
  • Biology, Medicine
  • Nature Medicine
  • 2011 (First Publication: 1 September 2011)
  • Previous studies have proposed roles for hypothalamic reactive oxygen species (ROS) in the modulation of circuit activity of the melanocortin system. Here we show that suppression of ROS diminishesExpand
  • Tony Tiganis, Anton M Bennett, Kodimangalam S. Ravichandran, Nicholas K. Tonks
  • Biology, Medicine
  • Molecular and Cellular Biology
  • 1998 (First Publication: 1 March 1998)
  • ABSTRACT T-cell protein tyrosine phosphatase (TCPTP) exists as two forms generated by alternative splicing: a 48-kDa endoplasmic reticulum (ER)-associated form (TC48) and a 45-kDa nuclear formExpand
  • Anton M Bennett, T L Tang, Sayaka Sugimoto, Christopher T Walsh, Benjamin G Neel
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 1994 (First Publication: 19 July 1994)
  • Protein-tyrosine-phosphatase SHPTP2 (Syp/PTP-1D/PTP2C) is the homologue of the Drosophila corkscrew (csw) gene product, which transmits positive signals from receptor tyrosine kinases. Likewise,Expand
  • Sivanagarani Kolli, Christina Ivins Zito, Marieke H Mossink, Erik A. C. Wiemer, Anton M Bennett
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 2004 (First Publication: 9 July 2004)
  • The catalytic activity of the Src homology 2 (SH2) domain-containing tyrosine phosphatase, SHP-2, is required for virtually all of its signaling effects. Elucidating the molecular mechanisms of SHP-2Expand
  • Robert J. Lechleider, Sayaka Sugimoto, +5 authors Benjamin G Neel
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1993 (First Publication: 15 October 1993)
  • Much progress has been made in elucidating early events in signal transduction by growth factor receptors with intrinsic tyrosine kinase activity. Upon ligand addition, these receptors dimerize andExpand