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Haemostatic changes in septic patients are complex, with both procoagulant and anticoagulant changes. Thirty-eight patients with severe sepsis and 32 controls were investigated by coagulation screens, individual factor assays, calibrated automated thrombography (CAT), whole blood low-dose-tissue factor activated (LD-TFA) Rotem and LD-TFA waveform analysis.(More)
This study assessed the effect on coagulation tests of fresh frozen plasma (FFP), given according to guidelines compared with higher doses in critically ill patients. Group 1 (10 patients) received 12.2 ml/kg and group 2 (12 patients) 33.5 ml/kg FFP. Prothrombin time, activated partial thromboplastin time and factors I-XII were measured before and after FFP(More)
OBJECTIVE To identify reliable predictors of outcome in comatose patients after cardiac arrest using a single routine EEG and standardized interpretation according to the terminology proposed by the American Clinical Neurophysiology Society. METHODS In this cohort study, 4 EEG specialists, blinded to outcome, evaluated prospectively recorded EEGs in the(More)
Boerhaave's syndrome is the rare and often fatal condition of spontaneous esophageal rupture. Meckler's triad of vomiting, pain and subcutaneous emphysema are characteristic features of Boerhaave's syndrome. When these symptoms are absent, diagnosis is frequently late and often occurs as the result of incidental investigation. This contributes to the(More)
duration of antibiotic therapy without a dimin-u tion in effi cacy decreases cost, side eff ects, antibiotic related diarrhoea, and bacterial resistance. Havey and colleagues [1] reported the results of a systematic review and meta-analysis of antibiotic duration in bacteraemia and deduced short course therapy (<7 days) might be as eff ective as longer(More)
Surgical tracheostomy in critically ill adults has largely been replaced by physicians performing percutaneous dilatational tracheostomy (PDT) at the bedside. Complications associated with this technique include haemorrhage, wound infection, barotrauma, false passage, ruptured tracheal ring and bacteraemia. Prophylactic antibiotics are not generally used(More)
1] recently examined the eff ec-tive dose of enoxaparin for thromboprophylaxis in critically ill patients recorded over 24 hours. Th e study concluded that the standard dose of 40 mg led to sub-therapeutic anti-factor Xa activity (aFXa) and 60 mg daily was optimal. Th e high rate of thromboembolic disease observed in critically ill patients could thus be(More)
In their recent study, Otto and colleagues suggested that the adverse effects of hyperglycaemia on immune function may be mediated by hyperosmotic stress [1]. In granulocytes both oxidative burst and phagocytosis were suppressed by hyper-osmolar stress with mannitol, but no significant effect was observed on cytokine release from peripheral blood(More)