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The mutation and overexpression of the epidermal growth factor receptor (EGFR) are associated with the development of a variety of cancers, making this prototypical dimerization-activated receptor tyrosine kinase a prominent target of cancer drugs. Using long-timescale molecular dynamics simulations, we find that the N lobe dimerization interface of the(More)
How the epidermal growth factor receptor (EGFR) activates is incompletely understood. The intracellular portion of the receptor is intrinsically active in solution, and to study its regulation, we measured autophosphorylation as a function of EGFR surface density in cells. Without EGF, intact EGFR escapes inhibition only at high surface densities. Although(More)
Dimerization-driven activation of the intracellular kinase domains of the epidermal growth factor receptor (EGFR) upon extracellular ligand binding is crucial to cellular pathways regulating proliferation, migration, and differentiation. Inactive EGFR can exist as both monomers and dimers, suggesting that the mechanism regulating EGFR activity may be(More)
The receptor tyrosine kinase Her2, an intensely pursued drug target, differs from other members of the EGFR family in that it does not bind EGF-like ligands, relying instead on heterodimerization with other (ligand-bound) EGFR-family receptors for activation. The structural basis for Her2 heterodimerization, however, remains poorly understood. The(More)
The epidermal growth factor receptor (EGFR) plays a key role in regulating cell proliferation, migration, and differentiation, and aberrant EGFR signaling is implicated in a variety of cancers. EGFR signaling is triggered by extracellular ligand binding, which promotes EGFR dimerization and activation. Ligand-binding measurements are consistent with a(More)
Epidermal growth factor receptor (EGFR) signalling is activated by ligand-induced receptor dimerization. Notably, ligand binding also induces EGFR oligomerization, but the structures and functions of the oligomers are poorly understood. Here, we use fluorophore localization imaging with photobleaching to probe the structure of EGFR oligomers. We find that(More)
Evoked potentials (EPs) of the brain in response to visual neutral and emotionally meaningful (threatening) stimuli were studied in order to clarify neurophysiological disturbances of affective perception during the psychotic state in schizophrenic patients with severe paranoid–hallucinatory syndrome who did not receive neuroleptic therapy. Analysis of the(More)
We report here studies of the early and later stages of cerebral information processes during passive reading of concrete words in healthy subjects and patients with schizophrenia using an event-related brain potentials method. Comparative analysis of the P100, N170, P200, and P300 components in the implicit situation showed that the latencies of the early(More)
The latencies and amplitudes of the P100 and N170 components of event related potentials (ERPs) upon presentation of neutral and threatening visual stimuli have been studied in healthy persons and patients with schizophrenia. The studied patients had acute psychosis with a predominance of hallucinatory-paranoid syndrome and did not receive antipsychotic(More)
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