Anton A. van Steenhoven

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Cancer chemotherapy treatment often leads to hair loss, which may be prevented by cooling the scalp during drug administration. The current hypothesis for the hair preservative effect of scalp cooling is that cooling of the scalp skin reduces blood flow (perfusion) and chemical reaction rates. Reduced perfusion leads to less drugs available for uptake,(More)
The metabolic and temperature response to mild cold were investigated in summer and winter in a moderate oceanic climate. Subjects were 10 women and 10 men, aged 19-36 years and BMI 17-32 kg/m2. Metabolic rate (MR) and body temperatures were measured continuously in a climate chamber with an ambient temperature of 22 degrees C for 1 h and subsequently 3 h(More)
Many researchers have already attempted to model vasoconstriction responses, commonly using the mathematical representation proposed by Stolwijk (1971 NASA Contractor Report CR-1855 (Washington, DC: NASA)). Model makers based the parameter values in this formulation either on estimations or by attributing the difference between their passive models and(More)
During mild cold exposure, elderly are at risk of hypothermia. In humans, glabrous skin at the hands is well adapted as a heat exchanger. Evidence exists that elderly show equal vasoconstriction due to local cooling at the ventral forearm, yet no age effects on vasoconstriction at hand skin have been studied. Here, we tested the hypotheses that at hand(More)
We study the properties of a hard-sphere dense gas near the hard walls of micro and nano-channels. Analytical techniques , Monte Carlo (MC) methods and molecular dynamics (MD) simulation methods have been used to characterize the influence of the characteristic parameters such as number density, reduced density, width of the system and molecular diameter,(More)
There is a tendency to cool mechanical and electrical components by microchannels. When the channel size decreases, the continuum approach starts to fail and particle based methods should be used. In this paper, a dense gas in micro and nano-channels is modelled by molecular dynamics and Monte Carlo simulations. It is shown that in the limit situation both(More)
Skin blood flow (SBF) is a key player in human thermoregulation during mild thermal challenges. Various numerical models of SBF regulation exist. However, none explicitly incorporates the neurophysiology of thermal reception. This study tested a new SBF model that is in line with experimental data on thermal reception and the neurophysiological pathways(More)
To the Editor: During surgery under general anesthesia, thermal imbalances within the patient's body are common. These imbalances are caused by a variety of factors, including exposure to a cold operating environment and heat loss from surgical incisions. Perhaps the most important thermal imbalance is hypothermia, resulting initially from redistribution of(More)
Introduction: In humans skin blood flow (SBF) plays a major role in body heat loss. Therefore the accuracy of models of human thermoregulation depends for a great deal on their ability to predict skin blood flow. Most SBF-models use body temperatures directly for calculation of skin perfusion. However, humans do not sense temperature directly, yet the(More)