Learn More
OBJECTIVES To show how hypoalbuminemia lowers the anion gap, which can mask a significant gap acidosis; and to derive a correction factor for it. DESIGN Observational study. SETTING Intensive care unit in a university-affiliated hospital. SUBJECTS Nine normal subjects and 152 critically ill patients (265 measurements). INTERVENTIONS None. (More)
INTRODUCTION Procalcitonin (PCT) and C-reactive protein (CRP) are established markers of infection in the general population. In contrast, several studies reported falsely increased PCT levels in patients receiving T-cell antibodies. We evaluated the validity of these markers in patients scheduled for hemopoietic stem cell transplantation receiving(More)
We compare two commonly used diagnostic approaches, one relying on plasma bicarbonate concentration and "anion gap," the other on "base excess," with a third method based on physicochemical principles, for their value in detecting complex metabolic acid-base disturbances. We analyzed arterial blood samples from 152 patients and nine normal subjects for pH,(More)
OBJECTIVE Systemic inflammatory response syndrome (SIRS) and sepsis remain the leading cause of death in the critically ill. A reduction in the antioxidant capacity, including selenoenzymes that are dependent on selenium (Se), could be a contributing factor. Se supplementation in septic patients have yielded conflicting results. We hypothesized that a(More)
A quantitative evaluation of metabolic acid-base component is described. The model is based on Stewart's analysis of acid-base chemistry. The metabolic component of acid-base disturbances is divided into four partial metabolic disorders; they can result from abnormal concentrations of chloride, albumin and phosphate disturbances, or from appearance of(More)
OBJECTIVE Low levels of selenium (Se) and glutathione peroxidase (GSHPx), a key selenoenzyme, were documented in systemic inflammatory response syndrome (SIRS) and sepsis, both associated with high mortality. Se supplementation had mixed effects on outcome. We hypothesized that Se supplementation could have a different impact on biomarkers and 28-day(More)
—The continuous growth in air traffic is gradually exhausting available airport capacity. If the air traffic growth remains on the expected level, many of large world's airports would not be able to handle increased traffic demand if no radical solution is found. The environmental, political and economical constraints more then ever inhibit the construction(More)