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Peripheral biomarkers in Autism: secreted amyloid precursor protein-alpha as a probable key player in early diagnosis.
Autism is a pervasive developmental disorder characterized by impairments in socialization and communication. There is currently no single molecular marker or laboratory tool capable of diagnosingExpand
Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism
Maternal immune activation (MIA) can affect fetal brain development and thus behavior of young and adult offspring. Reports have shown that increased Interleukin-6 (IL-6) in the maternal serum playsExpand
GFAP expression and social deficits in transgenic mice overexpressing human sAPPα
Autistic individuals display impaired social interactions and language, and restricted, stereotyped behaviors. Elevated levels of secreted amyloid precursor protein‐alpha (sAPPα), the product ofExpand
Aberrant T‐lymphocyte development and function in mice overexpressing human soluble amyloid precursor protein‐α: implications for autism
Abnormalities in T‐lymphocyte populations and function are observed in autism. Soluble amyloid precursor protein α (sAPP‐α) is elevated in some patients with autism and is known to be produced byExpand
Potential Autoepitope within the Extracellular Region of Contactin-Associated Protein-like 2 in Mice
Aims Implicated in autoimmune encephalitis, neuromyotonia and genetic forms of autism, here we report that contactin-associated protein-like 2 (CNTNAP2) contains a potential autoepitope within theExpand
Behavioral and Immunological Phenotypes of Transgenic Mice Overexpressing Human Secreted Amyloid Precursor Protein Alpha: Implications for Autism
DEDICATION Phil 1:3 – 6: I thank my God every time I remember you. In all my prayers for all of you, I always pray with joy because of your partnership in the gospel from the first day until now,Expand