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  • Antoine Taly, Pierre-Jean Corringer, Denis Guédin, Pierre Lestage, J. -p. Changeux
  • Medicine, Chemistry
  • Nature Reviews Drug Discovery
  • 2009 (First Publication: 1 September 2009)
  • Nicotinic receptors — a family of ligand-gated ion channels that mediate the effects of the neurotransmitter acetylcholine — are among the most well understood allosteric membrane proteins from aExpand
  • Nicolas Calimet, Manuel José Vieira Simões, Jean-Pierre Changeux, Martin Karplus, Antoine Taly, Marco Cecchini
  • Medicine, Chemistry
  • Proceedings of the National Academy of Sciences
  • 2013 (First Publication: 16 September 2013)
  • Significance Pentameric ligand-gated ion channels (pLGICs) control membrane conductance in living systems from bacteria to humans. Molecular dynamics simulations based on the structures of theExpand
  • Thomas Grutter, Lia Prado de Carvalho, Virginie Dufresne, Antoine Taly, Stuart J. Edelstein, Jean-Pierre Changeux
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2005 (First Publication: 13 December 2005)
  • Neurotransmitters such as acetylcholine (ACh) and glycine mediate fast synaptic neurotransmission by activating pentameric ligand-gated ion channels (LGICs). These receptors are allostericExpand