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OBJECTIVE To analyse the efficacy and tolerance of infliximab in refractory Takayasu arteritis (TA). METHODS French multicentre retrospective study that included patients with TA. Clinical disease activity was defined as new vascular and/or constitutional signs. RESULTS Fifteen patients with TA [median age 41 (range 17-61) years; 13 women] were(More)
BACKGROUND Dendritic cells (DC) and regulatory cells (Treg) play pivotal roles in controlling both normal and autoimmune adaptive immune responses. DC are the main antigen-presenting cells to T cells, and they also control Treg functions. In this study, we examined the frequency and phenotype of DC subsets, and the frequency and function of Treg from(More)
Autoimmune pancreatitis (AIP) is a syndrome characterised by an enlarged pancreas with an irregular narrowing of the main pancreatic duct, a high serum IgG4 concentration and IgG4-positive plasma cell tissue infiltration. A wide variety of lesions have been associated with AIP, including pulmonary lesions. 1 Consequently, the terms " IgG4-positive(More)
OBJECTIVES Rituximab has been shown to induce remission of ANCA-associated vasculitides (AAVs). Our study was undertaken to describe AAV clinical responses to rituximab used for remission-induction and/or maintenance therapy, assess rituximab's safety profile and evaluate French clinical practices. METHODS This retrospective study concerned AAV patients(More)
OBJECTIVE To describe characteristics, risk factors, and treatment outcome of progressive multifocal leukoencephalopathy (PML) complicating sarcoidosis. METHODS A retrospective chart and literature review was performed. Patients were identified through records from physicians of the Groupe Sarcoïdose Francophone. Each case was compared with 3 controls. (More)
The classification of pulmonary hypertension (PH) has recently been updated and PH associated with haematological disorders is classified as category V [1]. T-cell large granular lymphocytes (LGLs) are a morphologically distinct subset of normal peripheral blood mononuclear cells classified into two major lineages based on the presence of the CD3 receptor:(More)
OBJECTIVE Dendritic cells (DCs) are critical effectors of innate and adaptive immunity playing crucial roles in autoimmune responses. We previously showed that blood DC numbers were reduced in autoimmune antineutrophil cytoplasmic autoantibody-associated vasculitis (AAV). Here, we assessed toll-like receptor (TLR) responsiveness of blood DCs from patients(More)
A few reports suggest combination of ANCA-associated vasculitis (AAV) and neutrophilic dermatoses (ND). We aimed to describe the main characteristics of patients presenting with both AAV and ND in a French cohort and through a systematic literature review, and to discuss the possible common pathogenic process involved. We conducted a retrospective study of(More)
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