Antoine Le Bouil

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The cumulative pharmacokinetic pattern of oxaliplatin, a new diamminecyclohexane platinum derivative, was studied in patients with metastatic colorectal cancer. Oxaliplatin was administered by i. v. infusion (130 mg/m2) over 2 h every 3 weeks, and 5-fluorouracil and leucovorin were administered weekly. A very sensitive method, inductively coupled(More)
Roland Lehoucq, Jérôme Weiss, Bérengère Dubrulle, Axelle Amon, Antoine Le Bouil , Jérôme Crassous, David Amitrano and François Graner* 1 Laboratoire AIM-Paris-Saclay, CEA/DSM/Irfu, CNRS UMR 7158, Université Paris Diderot, CEA Saclay, Gif-sur-Yvette, France 2 Laboratoire de Glaciologie et Géophysique de l’Environnement, CNRS UMR 5183, Université Joseph(More)
Thyroid hormones are involved in copper and zinc distribution in rat tissues. We examined the influence of thyroparathyroidectomy (TPTY) and of a replacement therapy by T4 on Cu and Zn organ distribution. MT levels were also measured both in basal conditions and after induction by cadmium. The results confirm that a lack of T4 modified Cu and Zn in serum(More)
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