Antje Pieconka

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BACKGROUND To avoid pathological platelet aggregation by von Willebrand factor (VWF), VWF multimers are regulated in size and reactivity for adhesion by ADAMTS13-mediated proteolysis in a shear flow dependent manner. OBJECTIVE AND METHODS We examined whether tensile stress in VWF under shear flow activates the VWF A2 domain for cleavage by ADAMTS13 using(More)
The stepwise diagnosis of von Willebrand disease (vWD) includes patient and family history, screening procedures (bleeding time, filter tests, platelet counts, activated partial thromboplastin time [aPTT]), confirmatory tests (von Willebrand factor [vWF]:antigen [Ag], vWF:ristocetin cofactor activity assay [RCo], vWF:collagen-binding test [CB],(More)
Among the different phenotypes of von Willebrand disease (VWD) type 2A, we identified a particular subgroup with a high frequency of 29%, characterized by a relative decrease of large von Willebrand factor (VWF) multimers and decreased A Disintegrin And Metalloproteinase with ThromboSpondin type 1 motifs, member 13 (ADAMTS13)-mediated proteolysis previously(More)
The response of the rhabdomyosarcoma R1H of the rat to hyperfractionated irradiation with different time intervals between the two daily fractions has been investigated. All tumours were exposed to irradiation 5 days per week over 6 weeks. A standard treatment of 30 fractions, i.e. one fraction per day, of 1.83-2.75 Gy (200 kVp X-rays) was compared with a(More)
BACKGROUND The response of an experimental tumor to hyperfractionated irradiation with different time intervals between the two daily fractions has been investigated. MATERIAL AND METHODS Tumors were exposed to irradiation five days per week over six weeks. A standard treatment of 30 fractions, i.e. one fraction per day (200 kVp X-rays) was compared with(More)
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