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Chemosystematic Value of Flavonoids from Crataegus x macrocarpa (Rosaceae) with special Emphasis on (R)‐ and (S)‐Eriodictyol‐7‐O‐glucuronide and Luteolin‐7‐O‐glucuronide
The chemotaxonomic investigation of Crataegus x macrocarpa, a hybrid of C. laevigata and C. rhipidophylla, presents the qualitative and quantitative composition of its flavonoid pattern in…
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Modulation of GABAA-receptors by honokiol and derivatives: subtype selectivity and structure-activity relationship.
TLDR
31 was most efficient on α(2)β(2)-receptors, suggesting a role of the acetamido group in subunit-dependent receptor modulation, and a model with an overall classification accuracy of 91% showed three hydrophobic regions, one acceptor and one donor region.
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Mechanisms of osteoclastogenesis inhibition by a novel class of biphenyl-type cannabinoid CB(2) receptor inverse agonists.
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4′′′‐Acetylvitexin‐2″‐O‐rhamnoside, Isoorientin, Orientin, and 8‐Methoxykaempferol‐3‐O‐glucoside as Markers for the Differentiation of Crataegus monogyna and Crataegus pentagyna from Crataegus…
TLDR
The qualitative and quantitative flavonoid fingerprint of Crataegus monogyna and C. pentagyna is presented and laevigata offers an appropriate tool for additional differentiation from C.pentagyna and the main flavonoids 7, 8, and 12 could be proposed as markers for C.monogyna.
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In vitro Antioxidant and Antiproliferative Activities of Flavonoids from Ailanthus excelsa (Roxb.) (Simaroubaceae) Leaves
TLDR
The potential antiproliferative activity of the A. excelsa extract and isolated flavonoids against five human cancer cell lines such as ACHN, COR-L23, A375, C32, and A549 was investigated in vitro by the SRB assay.
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Induction of Caspase-8 and Death Receptors by a New Dammarane Skeleton from the Dried Fruits of Forsythia koreana
TLDR
Cabralealactone 3-acetate-24-methyl ether and ursolic acid were found to be active against human breast cancer cells (MCF-7) and the cytotoxicity was associated with the activation of caspase-8, the induction of the death receptors DR4 and DR5, as well as DNA fragmentation, and was thus due to apoptosis rather than necrosis.
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NMR and Radical Scavenging Activities of Patuletin from Urtica urens. Against Aflatoxin B1
TLDR
It is concluded that patuletin possesses an antioxidant activity and free radical scavenging effects in AFB1-treated rats that can be observed at a dose as low as 7.5 mg/kg b.w.
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Synthetic Transformations of Abietic Acid. Part 5. Structure Modification and Ozonization.
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Synthesis of Tetrahydrohonokiol Derivates and Their Evaluation for Cytotoxic Activity against CCRF-CEM Leukemia, U251 Glioblastoma and HCT-116 Colon Cancer Cells
TLDR
18 derivatives of honokiol derivatives, of which 13 were previously undescribed compounds, were evaluated against CCRF-CEM leukemia cells, U251 glioblastoma and HCT-116 colon cancer cells and revealed no significant cytotoxic effects.
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Two New Cyclic Amino Acids from the seeds and Antiviral Activity of methanolic extract of the roots of Zizyphus spinachristi
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