Antje Elitzsch

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BACKGROUND Angiogenesis represents the crucial step in the pathogenesis of endometriosis, because endometriotic lesions require neovascularization to establish, proliferate and invade inside the peritoneal cavity. To elucidate the role of angiogenic factors, we investigated in vivo whether blockade of vascular endothelial growth factor (VEGF), fibroblast(More)
OBJECTIVE To investigate the effects of selective cyclo-oxygenase-2 (COX-2) inhibition on the angiogenesis and proliferation of endometrial grafts. DESIGN Intravital fluorescence microscopic study. SETTING Institute for Clinical and Experimental Surgery, University of Saarland, Homburg/Saar, Germany. ANIMALS Syrian golden hamsters. INTERVENTIONS(More)
BACKGROUND AND PURPOSE Rapamycin is a widely used drug with antifungal, immunosuppressant and antiangiogenic effects. Herein, we studied whether immunosuppressive doses of rapamycin are capable of influencing endometriotic lesions. EXPERIMENTAL APPROACH We tested in vitro the potential of rapamycin to inhibit endothelial cell sprouting using the aortic(More)
OBJECTIVE To establish a novel endometriosis model that allows for repetitive in vivo analyses of angiogenesis in ectopic endometrial tissue. DESIGN Intravital fluorescence microscopic study. SETTING Institute for Clinical and Experimental Surgery, University of Saarland. ANIMAL(S) Female Syrian golden hamsters equipped with skinfold chambers. (More)
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