Anthony T. Nguyen

Leonard M. Hjelmeland2
Zeljka Smit-McBride2
Sharon L. Oltjen2
Roxana A. Radu1
2Leonard M. Hjelmeland
2Zeljka Smit-McBride
2Sharon L. Oltjen
1Roxana A. Radu
Learn More
PURPOSE To determine the localization of complement factor H (Cfh) mRNA and its protein in the mouse outer retina. METHODS Quantitative real-time PCR (qPCR) was used to determine the expression of Cfh and Cfh-related (Cfhr) transcripts in the RPE/choroid. In situ hybridization (ISH) was performed using the novel RNAscope 2.0 FFPE assay to localize the(More)
PURPOSE MicroRNA-34a (miR-34a) has been implicated in neurodegeneration. MiR-34a belongs to a signaling network involving p53 and Sirt-1. This network responds to DNA damage with further downstream signals that induce senescence or apoptosis. Our goal was to measure the expression level of miR-34a in the mouse retina and RPE as a function of age. METHODS(More)
  • 1