Anthony Novell

Learn More
We optimize the encapsulation and investigate the pharmacokinetics of 5-Fluorouracil (5-FU) delivered by thermosensitive stealth® liposomes (TSLs) designed to trigger drug release upon hyperthermia using focused ultrasound (FUS). 5-FU was encapsulated into liposomes made of(More)
PURPOSE This preclinical study aimed to evaluate placental oxygenation in pregnant rats by real-time photoacoustic (PA) imaging on different days of gestation and to specify variations in placental oxygen saturation under conditions of maternal hypoxia and hyperoxygenation. MATERIAL AND METHODS Placentas of fifteen Sprague-Dawley rats were examined on(More)
BACKGROUND Phase-change ultrasound contrast agents (PCCAs) offer a solution to the inherent limitations associated with using microbubbles for sonoporation; they are characterized by prolonged circulation lifetimes, and their nanometer-scale sizes may allow for passive accumulation in solid tumors. As a first step towards the goal of extravascular cell(More)
In ultrasound (US), a natural competition exists between the resolution of the image and the depth-of-field (DOF) into the medium, competition which is difficult to overcome with current US probe. Using large bandwidth transducer, such as cMUT, and the possibility to transmit several frequencies in one single transmission, we propose a multi-frequency(More)
— Conventionnal ultrasound contrast imaging systems use a fixed transmit frequency. However it is known that the insonified medium (microbubbles) is time-varying and therefore an adapted time-varying excitation is expected. We suggest an adaptive imaging technique which selects the optimal transmit frequency that maximizes the contrast tissue ratio (CTR).(More)
  • 1