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BACKGROUND Laboratory evidence suggests that reduced phosphodiesterase type 5 (PDE5) expression increases the invasiveness of melanoma cells; hence, pharmacological inhibition of PDE5 could affect melanoma risk. Two major epidemiological studies have investigated this and come to differing conclusions. We therefore aimed to investigate whether PDE5(More)
Acquiring the behavioral significance of sound has repeatedly been shown to correlate with long term changes in response properties of neurons in the adult primary auditory cortex. However, the molecular and cellular basis for such changes is still poorly understood. To address this, we have begun examining the auditory cortical expression of an(More)
OBJECTIVE  To quantify how a period of intense media coverage of controversy over the risk:benefit balance of statins affected their use. DESIGN  Interrupted time series analysis of prospectively collected electronic data from primary care. SETTING  Clinical Practice Research Datalink (CPRD) in the United Kingdom. PARTICIPANTS  Patients newly eligible(More)
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