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BACKGROUND Laboratory evidence suggests that reduced phosphodiesterase type 5 (PDE5) expression increases the invasiveness of melanoma cells; hence, pharmacological inhibition of PDE5 could affect melanoma risk. Two major epidemiological studies have investigated this and come to differing conclusions. We therefore aimed to investigate whether PDE5(More)
The effect of three intrauterine contraceptive devices (I.U.D.)-Lippes D, Dalkon Shield, and Copper 7-on menstrual blood-loss has been studied serially by objective methods in 279 women. All the women had a minimum of two cycles following delivery, abortion, cessation of lactation, or previous pill or I.U.D. use. All pads and tampons used for two further(More)
OBJECTIVE  To quantify how a period of intense media coverage of controversy over the risk:benefit balance of statins affected their use. DESIGN  Interrupted time series analysis of prospectively collected electronic data from primary care. SETTING  Clinical Practice Research Datalink (CPRD) in the United Kingdom. PARTICIPANTS  Patients newly eligible(More)
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