Anthony M. Middleton

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As a result of the continuing information explosion, many organizations now have the need to process and analyze massive volumes of data. These data-intensive computing requirements can be addressed by scalable systems based on hardware clusters of commodity servers coupled with system software to provide a distributed file storage system, job execution(More)
In this paper we develop a model of mesendoderm specification in Xenopus laevis based on an existing gene regulation network. The mesendoderm is a population of cells that may contribute to either the mesoderm or endoderm. The model that we develop encompasses the time evolution of transcription factor concentrations in a single cell and is shown to have(More)
As a result of the continuing information explosion, many organizations now have the need to process and analyze massive volumes of data. These data-intensive computing requirements can be addressed by scalable systems based on hardware clusters of commodity servers coupled with system software to provide a distributed file storage system, job execution(More)
Nodal signals are key regulators of mesoderm and endoderm development in vertebrate embryos. It has been observed experimentally that in Xenopus embryos the spatial range of Nodal signals is restricted by the signal Antivin (also known as Lefty). Nodal signals can activate both Nodal and Antivin, whereas Antivin is thought to antagonise Nodal by binding(More)
Executive Summary As a result of the continuing information explosion, many organizations are drowning in data and the resulting " data gap " or inability to process this information and use it effectively is increasing at an alarming rate. Data-intensive computing represents a new computing paradigm which can address the data gap using scalable parallel(More)
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