Anthony J. Sherbondy

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For more than a century, neurologists have hypothesized that the arcuate fasciculus carries signals that are essential for language function; however, the relevance of the pathway for particular behaviors is highly controversial. The primary objective of this study was to use diffusion tensor imaging to examine the relationship between individual variation(More)
Diffusion tensor imaging (DTI) is a magnetic resonance imaging method that can be used to measure local information about the structure of white matter within the human brain. Combining DTI data with the computational methods of MR tractography, neuroscientists can estimate the locations and sizes of nerve bundles (white matter pathways) that course through(More)
PURPOSE To compare the performance of radiologists and of a computer-aided detection (CAD) algorithm for pulmonary nodule detection on thin-section thoracic computed tomographic (CT) scans. MATERIALS AND METHODS The study was approved by the institutional review board. The requirement of informed consent was waived. Twenty outpatients (age range, 15-91(More)
Measuring the properties of the white matter pathways from retina to cortex in the living human brain will have many uses for understanding visual performance and guiding clinical treatment. For example, identifying the Meyer's loop portion of the optic radiation (OR) has clinical significance because of the large number of temporal lobe resections. We use(More)
Magnetic resonance diffusion-weighted imaging coupled with fiber tractography (DFT) is the only non-invasive method for measuring white matter pathways in the living human brain. DFT is often used to discover new pathways. But there are also many applications, particularly in visual neuroscience, in which we are confident that two brain regions are(More)
Segmentation of structures from measured volume data, such as anatomy in medical imaging, is a challenging data-dependent task. In this paper, we present a segmentation method that leverages the parallel processing capabilities of modern programmable graphics hardware in order to run significantly faster than previous methods. In addition, collocating the(More)
Diffusion Tensor Imaging (DTI) is a magnetic resonance imaging method that can be used to measure local information about the structure of white matter within the human brain. Combining DTI data with the computational methods of MR tractography, neuroscientists can estimate the locations and sizes of nerve bundles (white matter pathways) that course through(More)
This paper presents MicroTrack, an algorithm that combines global tractography and direct microstructure estimation using diffusion-weighted imaging data. Previous work recovers connectivity via tractography independently from estimating microstructure features, such as axon diameter distribution and density. However, the two estimates have great potential(More)
Virtual bronchoscopy (VB) has emerged as a paradigm for more effective 3D CT image evaluation. Systematic evaluation of a 3D CT chest image using VB techniques, however, requires precomputed guidance data. This guidance data takes the form of central axes, or centerlines, through the major airways. We propose an axes-generation algorithm for VB assessment(More)
Estimating the complete set of white matter fascicles (the projectome) from diffusion data requires evaluating an enormous number of potential pathways; consequently, most algorithms use computationally efficient greedy methods to search for pathways. The limitation of this approach is that critical global parameters--such as data prediction error and white(More)