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INTRODUCTION Surveillance is an alternative to adjuvant radiotherapy for stage I testicular seminoma. We present the long-term results of seminoma surveillance, with emphasis on quantifying the risk of late relapse beyond 5 years. METHODS From 1981 to 1993, of 431 men with stage I testicular seminoma, 203 were managed by surveillance following radical(More)
PURPOSE To assess the feasibility, and potential implications, of using intra-prostatic fiducial markers, rather than bony landmarks, for the co-registration of computed tomography (CT) and magnetic resonance (MR) images in the radiation treatment planning of localized prostate cancer. METHODS All men treated with conformal therapy for localized prostate(More)
PURPOSE Ipsilateral techniques designed to restrict treatment to the primary tumor and neck on the same side have been used in selected cases of cases of carcinoma of the tonsillar region at our institution for many years. The primary purpose of this study is to evaluate the risk of failure in the opposite neck in cases selected for unilateral radiotherapy(More)
BACKGROUND Induction chemotherapy followed by concurrent chemoradiation (CRT) (sequential therapy) has been evaluated in the treatment of locoregionally-advanced squamous cell cancer of the head and neck (LA-SCCHN), with docetaxel, cisplatin (P) and 5-flurouracil (F) shown to be superior to PF doublet. Nab-paclitaxel (A) is a novel albumin-bound paclitaxel(More)
The calcium content of the central one third of the skeleton was measured using neutron activation analysis in 109 patients with idiopathic calcium nephrolithiasis. The bone mineral content (calcium bone index or CaBI, corrected for body size) was significantly decreased by 5.2% in 20- to 60-year-old patients with calcium nephrolithiasis (p less than 0.01).(More)
BACKGROUND The objective of this study was to identify clinical parameters that predict occult subarachnoid space or spinal cord (SAS/SC) compression, as determined by magnetic resonance imaging (MRI), in patients with metastatic prostate carcinoma. METHODS A prospective study was performed in which 68 patients with bone metastases from prostate carcinoma(More)
4091 Background: Despite trimodality therapy the prognosis for LAEC is poor. Adjuvant anti-VEGF strategies are under study in many cancers. In this completed phase II trial we report tolerability and efficacy of Su, a multitargeted tyrosine kinase inhibitor, following chemoradiation and surgery for LAEC. METHODS Included were patients (pts) with LAEC of(More)
The design and construction of a hospital clinical facility for in vivo prompt gamma neutron activation analysis for total body nitrogen (TBN) measurement is described. The use of 252Cf neutron sources gives a better signal-to-background ratio compared with 238Pu-Be sources of equal strength, thus yielding better reproducibility of measurements. By(More)
124 Background: We evaluated the role of MRI (plus/minus biopsy) in delineating tumour boundaries for focal salvage therapy of prostate cancer recurrence after external beam radiotherapy. METHODS Patients with biochemical failure after radiotherapy were enrolled in a prospective clinical trial mapping sites of local recurrence. An integrated diagnostic(More)