Anthony D. Okonmah

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Previous studies in vitro on the influence of extracellular protein binding of Teniposide (VM26) and Etoposide (VP16-213) on subsequent cellular uptake by experimental murine tumor cells [Cancer Res 38: 2549 (1978); Drug Metab Rev 8: 119 (1978)] suggested that a timed-sequential combination of VM26 and VP16-213 may increase the bioavailability of VP16-213.(More)
1. Pregnant Sprague-Dawley rats treated chronically with ethanol (3 g/kg daily for the last third of pregnancy) had decreased placental weights at birth (ca 23%). 2. Whole fetal brain levels of HVA and 5-HIAA were similarly decreased 32 and 38%, respectively. 3. MHPG levels were also marginally reduced (i.e. 15% decline). 4. In the presence of a potent type(More)
Cultured brain cells from rat fetuses of ethanol-treated mothers demonstrated more than 2-fold elevations in choline acetyltransferase (ChAT) activity relative to those of control (saline-exposed) fetal brain cells. When cells from control animals were incubated in vitro for 5 days with 0.1% ethanol, ChAT activity was found to increase more than 4-fold.(More)
The effect of ciclosporin (CS) on hepatic and renal glutathione was investigated in 36 male Sprague-Dawley rats weighing 200-250 g each. CS (120 micrograms/kg/day, i.p.) treatment caused a significant decrease in both hepatic and renal glutathione content. The rat hepatic glutathione levels decreased by 16% within 1 h of a single CS treatment and continued(More)
The immunosuppressive agent, Cyclosporin A, (CsA) has been associated with nephrotoxicity and hypertension. The mechanism for these effects are not known. We therefore determined the levels of the catecholamines; epinephrine (EPI), norepinephrine (NE) and dopamine (DA) and some of their metabolites; epinine, dihydroxyphenyl-acetic acid (DOPAC), homovanillic(More)
In the presence of ethanol, corticosterone and dexamethasone inhibit choline acetyltransferase and acetylcholinesterase activities in cultured fetal brain cells of the rat. These results suggest that corticosteroids may have an important influence on the activity of cholinergic enzymes in the fetal brain and may antagonize the effects of ethanol in this(More)
Harmaline, a known type A monoamine oxidase (MAO) inhibitor in adult brain of various species was found to elevate whole brain levels of dopamine and serotonin (5-HT) in rat fetuses of mothers injected 2-4 h before Caesarean delivery. Similar stimulatory effects were observed for the norepinephrine metabolite 3-methoxy-4-hydroxy-phenylglycol (MHPG),(More)
The effects of systemically administered haloperidol (haldol) and N-ethoxycarbonyl-2-ethoxy-1,2, dihydroquinoline (EEDQ) on serum testosterone level were studied in Sprague-Dawley adult male rats. Animals were injected intraperitoneally with either 0.1, 5 and 10 mg/kg of haldol or 0.5 and 5 mg/kg of EEDQ. Animals were sacrificed at 15, 60 min, 12, 24 or 48(More)
In the immature rat, CNS stimulants administration to pregnant mare serum gonadotropin (PMSG) primed rats resulted in significant (p<0.01) ovarian and uterine hypertrophy when compared to animals treated with PMSG only. Meanwhile precocious puberty was produced by pentylenetetrazol treatment alone. The results of this experiment may indicate that(More)
The effect of cyclosporin A on the content of glutathione was investigated in various regions of the brain of male Sprague-Dawley rats, weighing 275-300 g each. Treatment of rats with cyclosporin A (120 micrograms/kg/day, i.p.) resulted in approximately 50% decrease in the content of glutathione of the cerebellum within 1 hr, relative to time-matched(More)