Constraint handling is one of the major concerns when applying genetic algorithms (GAs) to solve constrained optimization problems. This paper proposes to use the gradient information derived from the constraint set to systematically repair infeasible solutions. The proposed repair procedure is embedded into a simple GA as a special operator. Experiments… (More)
Traumatic injury to the brain is a problem as old as humanity, but advances in cognitive neuroscience and a long-term view of the dynamic nature of the brain across the lifespan may change how the disorder is understood and treated.
—Ongoing, rapid advances in three-dimensional (3D) printing technology are making it inexpensive for lay people to manufacture 3D objects. However, the lack of tools to help non-technical users design interesting, complex objects represents a significant barrier preventing the public from benefiting from 3D printers. Previous work has shown that an… (More)
The optimal shelter locations for the flood evacuation planning are studied in this paper. We assume that the authority can control the traffic in certain part of the network while the evacuees choose which shelter to go and by which route. The shelter location problem is posed as a Stackelberg game, consisting of the leader (authority) determining the… (More)
Sepsis remains a poorly understood, enigmatic disease. One of the cascades crucially involved in its pathogenesis is the complement system. Especially the anaphylatoxin C5a has been shown to have numerous harmful effects during sepsis. We have investigated the impact of high levels of C5a on the adrenal medulla following cecal ligation and puncture… (More)
It is becoming increasingly clear that the autonomic nervous system and the immune system demonstrate cross-talk during inflammation by means of sympathetic and parasympathetic pathways. We investigated whether phagocytes are capable of de novo production of catecholamines, suggesting an autocrine/paracrine self-regulatory mechanism by catecholamines during… (More)
The large ribosomal subunit protein Rpl10p is required for subunit joining and 60S export in yeast. We have recently shown that Rpl10p as well as the cytoplasmic GTPase Lsg1p are required for releasing the 60S nuclear export adapter Nmd3p from subunits in the cytoplasm. Here, we more directly address the order of Nmd3p and Rpl10p recruitment to the subunit.… (More)
Path finding problems have many real-world applications in various fields, such as operations research, computer science, telecommunication, transportation, etc. In this paper, we examine three definitions of optimality for finding the optimal path under an uncertain environment. These three stochastic path finding models are formulated as the expected… (More)