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Three properties of interest in bioavailability studies using compartmental models are the area under the concentration curve, the maximum concentration, and the time to maximum concentration. Methods are described for finding designs that minimize the variance of the estimates of these quantities in such a model. These methods use prior information. Both(More)
We use the forward search to provide robust Mahalanobis distances to detect the presence of outliers in a sample of multivariate normal data. Theoretical results on order statistics and on estimation in truncated samples provide the distribution of our test statistic. We also introduce several new robust distances with associated distributional results.(More)
Adaptive designs are used in phase III clinical trials for skewing the allocation pattern toward the better treatments. We use optimum design theory to derive a skewed Bayesian biased-coin procedure for sequential designs with continuous responses. The skewed designs are used to provide adaptive designs, the performance of which is studied numerically and(More)
The forward search provides a series of robust parameter estimates based on increasing numbers of observations. The resulting series of robust Mahalanobis distances is used to cluster multivariate normal data. The method depends on envelopes of the distribution of the test statistics in forward plots. These envelopes can be found by simulation; flexible(More)
The paper considers the problem of testing for multiple outliers in a regression model and provides fast approximations to the null distribution of the minimum deletion residual used as a test statistic. Since direct simulation of each combination of number of observations and number of parameters is too time consuming, methods using simple normal samples(More)
Setting of process variables to meet a required specification of quality characteristic (or response variable) in a process, is one of the common problems in the process quality control. But generally there are more than one quality characteristics in the process and the experimenter attempts to optimize all of them simultaneously. Since response variables(More)
Many experimental programs in chromatography involve the estimation of a second-order response surface. The paper focuses on the use of the methods of optimal experimental design to find efficient response surface designs. We give tables of the properties of designs with two, three and four factors. References are given to tables of designs and to SAS(More)