Anthony Burke

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Protein-protein interactions (PPIs) are fundamental to the structure and function of protein complexes. Resolving the physical contacts between proteins as they occur in cells is critical to uncovering the molecular details underlying various cellular activities. To advance the study of PPIs in living cells, we have developed a new in vivo cross-linking(More)
The cross-linking Mass Spectrometry (XL-MS) technique extracts structural information from protein complexes without requiring highly purified samples, crystallinity, or large amounts of material. However, there are challenges to applying the technique to protein complexes in vitro, and those challenges become more daunting with in vivo experiments. Issues(More)
A squaraine dye incorporating two carboxylic acid attaching groups has been synthesised and used successfully in both liquid and solid-state solar cells, with solar energy to electricity conversion efficiencies (eta) under AM 1.5 G irradiation (100 mW cm(-2)) of 3.7 and 1.5% and short-circuit current densities (J(sc)s) of 8.6 and 4.2 mA cm(-2), with(More)
We present a device based study into the operation of liquid electrolyte dye-sensitized solar cells (DSSC's) using organic dyes. We find that, for these systems, it is entirely necessary to employ a compact TiO2 layer between the transparent fluorine doped SnO2 (FTO) anode and the electrolyte in order to reduce charge recombination losses. By incorporation(More)
In nature, cephalopods employ unique dynamic camouflage mechanisms. Herein, we draw inspiration from self-assembled structures found in cephalopods to fabricate tunable biomimetic camouflage coatings. The reflectance of these coatings is dynamically modulated between the visible and infrared regions of the electromagnetic spectrum in situ. Our studies(More)
Lycoperine A was synthesized through a highly convergent route in which a double alkylation of 2,6-dicyano-N-benzylpiperidine with the octahydroquinoline moiety gave the lycoperine skeleton. The octahydroquinoline was prepared by a desymmetrization reaction of 5-methylcyclohexane-1,3-dione. Hydrolysis, reductive amination, and cyclization gave lycoperine A(More)
ruthenium complexes and DNA. Jacqueline Barton and co-workers2 co-crystallized Δ-[Ru(bpy)2(dppz)] with the 12-mer DNA sequence d(CGGAAATTACCG) — a self-complementary double helix with two adenine:adenine (A:A) mismatches. An atomic-resolution structure analysis of the resulting co-crystal revealed a complex pattern of interactions between the ruthenium(More)