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Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes.
A significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several of which are known to control gene expression. The repertoire and regulation of lncRNAs inExpand
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Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks
Summary Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic β cells. β cell lncRNAs are often cell type specific and exhibit dynamic regulation duringExpand
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Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury
Summary Repair Schwann cells play a critical role in orchestrating nerve repair after injury, but the cellular and molecular processes that generate them are poorly understood. Here, we perform aExpand
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Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes
Genetic studies promise to provide insight into the molecular mechanisms underlying type 2 diabetes (T2D). Variants associated with T2D are often located in tissue-specific enhancer clusters orExpand
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Long Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes
The transcriptional programs of differentiated cells are tightly regulated by interactions between cell type-specific transcription factors and cis-regulatory elements. Long non-coding RNAs (lncRNAs)Expand
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HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer
Defects in transcriptional regulators of pancreatic exocrine differentiation have been implicated in pancreatic tumorigenesis, but the molecular mechanisms are poorly understood. The locus encodingExpand
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Urticaire chronique d’origine paranéoplasique : à propos d’un cas
Introduction L’urticaire chronique concernerait 0,1 a 0,5 % de la population generale et apparait donc comme une problematique frequente en medecine interne et en dermatologie. Les etiologiesExpand
Plasticité et reprogrammation des cellules intestinales
Les cellules endocrines pancreatiques et intestinales partagent de nombreuses caracteristiques moleculaires, cellulaires et fonctionnelles. Particulierement, leur differenciation repose sur desExpand