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Testicular germ cell tumors (TGCT) have been expected to have a strong underlying genetic component. We conducted a genome-wide scan among 277 TGCT cases and 919 controls and found that seven markers at 12p22 within KITLG (c-KIT ligand) reached genome-wide significance (P < 5.0 x 10(-8) in discovery). In independent replication, TGCT risk was increased(More)
Schizophrenia is a psychiatric disorder with onset in late adolescence and unclear etiology characterized by both positive and negative symptoms, as well as cognitive deficits. To identify copy number variations (CNVs) that increase the risk of schizophrenia, we performed a whole-genome CNV analysis on a cohort of 977 schizophrenia cases and 2,000 healthy(More)
BACKGROUND Mitochondrial genome sequence analysis is critical to the diagnostic evaluation of mitochondrial disease. Existing methodologies differ widely in throughput, complexity, cost efficiency, and sensitivity of heteroplasmy detection. Affymetrix MitoChip v2.0, which uses a sequencing-by-genotyping technology, allows potentially accurate and(More)
Galileo97 is a staticallyyscoped functional conceptual language. Functions are rst class values which can be passed as parameters, returned as values and embedded in data structures. Galileo97 is an interactive language. A session is a dialogue of questions and answers with the Galileo97 system. Galileo97 is a statically and strongly typed language. Every(More)
Recent research on curriculum-based measurement of oral reading fluency has revealed important issues in current passage development procedures, highlighting how dissimilar passages are problematic for monitoring student progress. The purpose of this paper is to describe statistical equating as an option for achieving equivalent scores across non-parallel(More)
Description The equate package contains functions for non-IRT equating under both random groups and nonequivalent groups with anchor test designs. Mean, linear, equipercentile and circle-arc equating are supported, as are methods for univariate and bivariate presmoothing of score distributions. Specific equating methods currently supported include Tucker,(More)
The R package equate (Albano, 2010) contains functions for non-IRT equating under random groups and nonequivalent groups designs. This package vignette introduces these designs and provides an overview of statistical equating with details about each of the supported equating methods. Examples demonstrate the basic functionality of the package.