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The method most frequently used for the coverage of trochanteric pressure sores is the tensor fascia lata (TFL) flap. The authors introduce a new, hatchet-shaped incision strategy for the TFL flap, which preserves the safe blood supply of the flap and keeps the flap mobile enough. The part of the flap including the muscle is adapted to the greater(More)
In the present study the therapeutic efficacy and the side effects of two antiretroviral compounds used in human acquired immunodeficiency syndrome (AIDS) research, 3'-azido-2',3'-dideoxythymidine (AZT, zidovudine, Retrovir) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA), were investigated in the treatment of cats naturally infected with feline(More)
One of the most frequently used flaps for the coverage of sacral skin and soft-tissue defects (primarily decubiti) is the gluteus maximus musculocutaneous flap. The authors have developed a new, hatchet-shaped incision direction for the flap and have been using it for 6 years in the surgical treatment of various pelvic-area defects with good results. At the(More)
Peripheral occlusive arterial disease (POAD) encompasses all stenotic and occlusive changes affecting the aorta and arteries supplying the extremities, and in 90% of the cases is due to atherosclerosis. In the majority of patients the lower extremities are involved, andonly every third patient has symptoms. Apart from its significance as an independent(More)
Based on previous animal and on preliminary human results a further human study was performed in order to confirm the relevant pharmacokinetic parameters and the lack of accumulation of letosteine after repeated administrations. Thus, six healthy male volunteers were given a single oral dose of 50 mg (100 microCi) 14C-letosteine in form of gelatine(More)
In the primary and early operative treatment of deep burns of the hand necrectomy is the main point. Grafting of skin is urgent, too, but it is secondary to necrectomy. The hazard to the deep structures on the hand make a primary flap plasty necessary. However, if it is about a relative indication or the personal and material conditions are missing, a(More)
The pharmacokinetics, metabolism and elimination of Itanoxone was studied after a single oral administration of the carbon-14-1 abelled drug (500 mg) in four male volunteers. The drug was absorbed fairly rapidly with a mean peak plasma level of 10.3±1.3 μg/ml between 3 and 4 hours after dosing. The pharmacokinetics can be described by a two-compartment open(More)
We summarize our 15 year experience in the surgical treatment of pressure ulcers of the pelvic region. The technique of suggested operations is described (sacral defect--gluteus maximus musculocutaneous V-Y advancement flap, trochanteric defect--tensor fascia lata musculofasciocutaneous transpositional flap, ischial defect--biceps femoris musculocutaneous(More)