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  • Rubem F. S. Menna-Barreto, Renata L S Goncalves, +4 authors Solange L de Castro
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 2009 (First Publication: 1 September 2009)
  • Despite ongoing efforts, the current treatment for Chagas disease is still unsatisfactory, mainly because of the severe side effects and variable efficacy of the available nitroheterocycles. OurExpand
  • Antônio Ventura Pinto, C N Pinto, M do C Pinto, R. Santa Rita, Cristina Pezzella, Solange L de Castro
  • Medicine, Chemistry
  • Arzneimittel-Forschung
  • 1997 (First Publication: 3 June 1997)
  • Continuing a program on the chemistry and biological activity of compounds from the Brazilian flora, the lytic activity against bloodstream forms of T. cruzi of nine new heterocyclic naphthooxazoleExpand
  • Karlos A L Ribeiro, Cenira M. de Carvalho, +7 authors Marília Oliveira Fonseca Goulart
  • Biology, Medicine
  • Acta tropica
  • 2009 (First Publication: 1 July 2009)
  • Larvicidal (against Aedes aegypti Linnaeus, 1762) and molluscicidal (against Biomphalaria glabrata Say, 1818) activities of several natural and synthetic naphthoquinones were measured, withExpand
  • Paula Fernandes Carneiro, Samara Braga do Nascimento, +7 authors Vítor F Ferreira
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry
  • 2012 (First Publication: 15 August 2012)
  • New oxirane derivatives were synthesized using six naphthoquinones as the starting materials. Our biological results showed that these oxiranes acted as trypanocidal agents against Trypanosoma cruziExpand
  • Eufrânio N. da Silva, Rubem F. S. Menna-Barreto, +7 authors Antônio Ventura Pinto
  • Medicine, Chemistry
  • European journal of medicinal chemistry
  • 2008 (First Publication: 1 August 2008)
  • [1,2,3]-Triazole derivatives of nor-beta-lapachone were synthesized and assayed against the infective bloodstream trypomastigote form of Trypanosoma cruzi, the etiological agent of Chagas disease.Expand