BACKGROUND Human communities consistently develop a detailed knowledge of the therapeutical and medicinal properties of the local flora and fauna, and these folk remedies often substitute medicines produced by the pharmaceutical industry. Animals (and their derived products) are essential ingredients in the preparation of many traditional remedies. The… (More)
Neuronal loss and alterations of the cortical neuropil were previously described on necropsic material from patients with senile dementia of the Alzheimer type, and the results compared to age-matched case controls. In frontal cortex biopsic material from our patients with Alzheimer's disease, the numerical densities of neurons and synapses were not… (More)
Apparently normal dendrites from the frontal cortex of 7 patients with Alzheimer's disease showed mitochondria with increased density matrices and paracrystalline inclusions in the intercristal space. Most of the inclusions were formed by parallel laminae, while others presented a polyhedric arrangement. Deposits of electron-dense flocculent material were… (More)
An ultrastructural study of a biopsy fragment from the cerebellar cortex of a patient with ataxia-telangiectasia was performed. There was a sharp reduction in the number of Purkinje cells and an increase in the number of Golgi epithelial cells. Despite the degeneration of Purkinje cell dendrites, the volumetric density of parallel fiber varicosities and the… (More)
Golgi studies of three cortical biopsies from patients with SSPE reveal an abnormal pyramidal dendritic domain, spine-loss, and reactive gliosis. These findings support results obtained in a previous ultrastructural study of this disease, and are in keeping with the pathological features observed in other situations in which mental changes occur.
The clinical features of 2 new cases of Sjögren-Larsson syndrome are described. Histopathological examination of the skin in 1 of the cases revealed an ichthyosis vulgaris, which does not agree with the clinical and genetic classification. In the same case, a neuroblastoma was the cause of death, and neuropathological examination showed a symmetrical… (More)