Antônia Oliveira Silva

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Extracellular plaques of amyloid-β and intraneuronal neurofibrillary tangles made from tau are the histopathological signatures of Alzheimer's disease. Plaques comprise amyloid-β fibrils that assemble from monomeric and oligomeric intermediates, and are prognostic indicators of Alzheimer's disease. Despite the importance of plaques to Alzheimer's disease,(More)
Prolactin (PRL) is a pleiotropic cytokine promoting cellular proliferation and differentiation. Because PRL activates the Src family of tyrosine kinases (SFK), we have studied the role of these kinases in PRL cell proliferation signaling. PRL induced [(3)H]thymidine incorporation upon transient transfection of BaF-3 cells with the PRL receptor. This effect(More)
Endocytosis modulates EGFR function by compartmentalizing and attenuating or enhancing its ligand-induced signaling. Here we show that it can also control the cell surface versus intracellular distribution of empty/inactive EGFR. Our previous observation that PKA inhibitors induce EGFR internalization prompted us to test phosphatidic acid (PA) generated by(More)
BACKGROUND The mental health of nursing staff members influences the work process outcomes. OBJECTIVE Identify the work related factors that harms the nursing team's mental health. METHODS Databases PubMed, Scopus, CINAHL and MEDLINE, by mating between the indexed descriptors in MeSH terms "mental health" and "occupational health nursing". 783 articles(More)
FULL METHODS Thioflavin T Assays Peptides were diluted from monomeric solutions in hexafluoroisopropanol (HFIP) into PBS to a final peptide concentration of 5 μM and then were incubated at 37° C for the indicated times. At each time point, samples of 100 μl each were placed in 96-well black-walled plates (Corning) taken, 5 μl of 200 μM thioflavin-T(More)
Galectins have been implicated in T cell homeostasis playing complementary pro-apoptotic roles. Here we show that galectin-8 (Gal-8) is a potent pro-apoptotic agent in Jurkat T cells inducing a complex phospholipase D/phosphatidic acid signaling pathway that has not been reported for any galectin before. Gal-8 increases phosphatidic signaling, which(More)
MEDIATED ERK 1/2 ACTIVATION SUPPORTED BY PKA DOWN REGULATION Andrés Norambuena, Claudia Metz, Lucas Vicuña, Antonia Silva, Evelyn Pardo, Claudia Oyanadel, Alfonso González 1,2,3 and Andrea Soza 1,2,3 Departamento de Inmunología Clínica y Reumatología, Facultad de Medicina; Centro de Regulación Celular y Patología and Centro de Envejecimiento y Regeneración,(More)
OBJECTIVE To measure the prevalence in frail elderly people, their consequences and associated demographic factors. METHODS This was an epidemiological and cross-sectional study with a probabilistic sample composed of 240 elderly people (≥ 60 years) living in Ribeirão Preto, Sao Paulo state. Data were collected between November 2010 and February 2011,(More)
The world population is aging rapidly, which poses a greater challenge for the institutions involved which, in turn, require new public health policies that include the prevention of falls. The objective of this study was to assess the risk of falls in the elderly. This epidemiological, cross-sectional study was performed at a family health unit, using a(More)
This study aimed to identify elders' social representations of quality of life. This is an exploratory study with a sample of 240 elders, of both sexes. For data collection we used a Free Association Test with Words, using the inductive stimulus 'quality of life" and sociodemographic variables. The interviews were analyzed with the software Alceste. Of the(More)