António Vaz-Carneiro

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PURPOSE Evaluate the clinical comparability of new antiepileptic drugs (AEDs) in partial refractory epilepsy. METHODS Systematic review of randomized trials (RCTs) comparing a new AED (add-on treatment) with placebo or another AED. PRIMARY OUTCOMES responder (≥50% seizure reduction) and withdrawal (tolerability) rates. Pooled estimates of odds ratios(More)
A recent meta-analysis of 4 studies published up to January 2004 suggests a negative association between coffee consumption and Alzheimer's disease, despite important heterogeneity in methods and results. Several epidemiological studies on this issue have been published since then, warranting an update of the insights on this topic. We conducted a(More)
Several studies conducted worldwide report an inverse association between caffeine/coffee consumption and the risk of developing Parkinson's disease (PD). However, heterogeneity and conflicting results between studies preclude a correct estimation of the strength of this association. We conducted a systematic review and meta-analysis of published(More)
BACKGROUND We systematically reviewed infliximab benefit in reducing hospitalizations and/or major surgery rates in patients with inflammatory bowel disease (IBD). METHODS A literature search to May 2012 was performed to identify all studies (experimental and observational) evaluating patients with IBD treated with infliximab and providing data on(More)
OBJECTIVE To systematically review longitudinal studies evaluating use of angiotensin converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) and risk of pneumonia. DESIGN Systematic review and meta-analysis. DATA SOURCES Medline through PubMed, Web of Science with conference proceedings (inception to June 2011), and US Food and Drug(More)
AIMS/HYPOTHESIS There are five systems to stratify the risk for the development of a diabetic foot ulcer (DFU). This study aimed to prospectively validate all of them in the same cohort of participants to allow their direct comparison. METHODS A retrospective cohort study was conducted on all patients with diabetes but without an active DFU attending our(More)
AIM We systematically review the available systems used to classify diabetic foot ulcers in order to synthesize their methodological qualitative issues and accuracy to predict lower extremity amputation, as this may represent a critical point in these patients' care. MATERIAL AND METHODS Two investigators searched, in EBSCO, ISI, PubMed and SCOPUS(More)
INTRODUCTION AND OBJECTIVE Non-adherence to drug treatment is a major health problem. In Europe, it has been estimated that 9% of cardiovascular events can be attributed to non-adherence. The complexity of dosing regimens is one of the factors identified as contributing to non-adherence. In this systematic review we aimed to assess the impact of dosing(More)
Smoking is one of the most important risk factors for various cardiovascular, cancer and respiratory diseases. There are a number of smoking cessation techniques involving psychological, pharmacological and behavioral interventions, with varying effectiveness and different costs. The electronic cigarettes are devices which produce a nicotine aerosol but(More)
BACKGROUND Chronic musculoskeletal pain is a prevalent condition and a major cause of disability and absence from the workplace worldwide. Opioids are frequently used to treat chronic pain, although adverse effects often restrict their long-term benefits. Tapentadol is an opioid and norepinephrine re-uptake inhibitor, which may cause a lower incidence (and(More)