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Smoothing filters have been extensively used in image and video analysis. In particular, directional smoothers have been employed in motion analysis, edge detection, line parameter estimation, and texture analysis. Such applications often necessitate the use of several directional filters oriented at different angles. However, applying a large number of(More)
Understanding how genetic variation contributes to phenotypic differences is a fundamental question in biology. Here, we set to predict fitness defects of an individual using mechanistic models of the impact of genetic variants combined with prior knowledge of gene function. We assembled a diverse panel of 696 ​Escherichia coli strains for which we(More)
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