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Separation of nadolol stereoisomers by chiral liquid chromatography at analytical and preparative scales.
The separation of the four nadolol stereoisomers on Chiralpak® AD by chiral liquid chromatography was carried out at both analytical and preparative scales. A screening of possible mobile-phase… Expand
Chiral Separation of Ketoprofen Enantiomers by Preparative and Simulated Moving Bed Chromatography
The pharmaceutical industry is now directed to the market of more safety and efficient drugs, based on single enantiomers. Ketoprofen, still used as a racemic pharmaceutical drug, belongs to the… Expand
Chiral separation of flurbiprofen enantiomers by preparative and simulated moving bed chromatography.
This study presents the chiral resolution of flurbiprofen enantiomers by preparative liquid chromatography using the simulated moving bed (SMB) technology. Flurbiprofen enantiomers are widely used as… Expand
Preparative separation of ketoprofen enantiomers: choice of mobile phase composition and measurement of competitive adsorption isotherms
The present work intends to investigate how mobile phase composition influences the adsorption behavior of ketoprofen enantiomers (a nonsteroidal anti-inflammatory drug) on an amylose-based chiral… Expand
Optimization of the mobile phase composition for preparative chiral separation of flurbiprofen enantiomers
Abstract This work presents the experimental and simulation results obtained for the optimization of the mobile phase composition for the preparative separation of flurbiprofen enantiomers by liquid… Expand
Simulated Moving Bed Technology: Principles, Design and Process Applications
Make more knowledge even in less time every day. You may not always spend your time and money to go abroad and get the experience and knowledge by yourself. Reading is a good alternative to do in… Expand
Separation of Nadolol Stereoisomers Using Chiralpak IA Chiral Stationary Phase.
Chiralpak IA adsorbent is used for both analytical and preparative chromatographic separation of nadolol stereoisomers. The results include a complete screening of the mobile phase composition for… Expand
Principles of Simulated Moving Bed
In this chapter the principles of simulated moving bed technology are presented, starting with the history of chromatography and the progress from batch to continuous chromatography (true moving bed,… Expand
Modeling and Simulation of Simulated Moving Bed Separation Processes
In this chapter the strategies of modeling simulated moving bed (SMB) processes are discussed. Models for transient SMB and equivalent true moving bed (TMB) processes are derived. Steady-state TMB… Expand
Design of Simulated Moving Bed for Binary or Pseudo-Binary Separations
In this chapter we review simulated moving bed (SMB) design methods for binary systems with particular focus on the “triangle theory” based on equilibrium models for linear and nonlinear adsorption… Expand