António Albino-Teixeira

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A comparison was made of the influence of candesartan, ZD7155, losartan and eprosartan on angiotensin II effects at pre- and postjunctional AT1 receptors of the rat tail artery. To study the anti-angiotensin II effect at prejunctional receptors, the tissues were preincubated with [3H]noradrenaline and then superfused and electrically stimulated (1 Hz, 2 ms,(More)
1. The study was undertaken to compare the beta-adrenoceptor-mediated facilitation of noradrenaline release in the tail artery of vehicle-treated rats and of rats rendered hypertensive by chronic administration of 1,3-dipropyl-8-sulphophenylxanthine (DPSPX). Artery rings were loaded with [3H]-noradrenaline, and five periods of electrical stimulation (1 Hz(More)
BACKGROUND AND PURPOSE Activation of the intrarenal renin-angiotensin system (RAS) and increased renal medullary hydrogen peroxide (H(2) O(2) ) contribute to hypertension. We examined whether H(2) O(2) mediated hypertension and intrarenal RAS activation induced by angiotensin II (Ang II). EXPERIMENTAL APPROACH Ang II (200 ng·kg(-1) ·min(-1) ) or saline(More)
1. Long-term treatment of rats with 1,3-dipropyl-8-sulphophenylxanthine (DPSPX), a non-selective antagonist of adenosine receptors, causes a hypertensive state. 2. In DPSPX-hypertensive rats, prejunctional alpha 2-adrenoceptors become supersensitive to the selective alpha 2-adrenoceptor agonist UK-14,304, while postjunctional adrenoceptor-mediated responses(More)
Sympathetic denervation of the rat heart was produced by 6-hydroxydopamine. In denervated ventricles abundant “atrial” granules were observed whereas in controls no such granules were seen. Denervated ventricles and atria showed a very high content of atrial natriuretic peptide-like immunoreactivity (> 10 times higher than in control animals). We suggest(More)
Adenosine has been shown recently to be the main factor responsible for the trophic effects of sympathetic innervation. As sympathetic denervation causes hypertrophic and hyperplastic changes reminiscent of those occurring in blood vessels of spontaneously hypertensive rats, we decided to study the effect of a continuous blockade of adenosine receptors on(More)
Nociceptive transmission from the spinal cord is controlled by supraspinal pain modulating systems that include the caudal ventrolateral medulla (CVLM). The neuropeptide angiotensin II (Ang II) has multiple effects in the CNS and at the medulla oblongata. Here we evaluated the expression of angiotensin type 1 (AT(1)) receptors in spinally-projecting CVLM(More)
The continuous infusion for 7 days of the adenosine receptor antagonist 1,3-dipropyl-8-sulfophenylxanthine (DPSPX) causes a sustained hypertension in rats, with an enhancement of sympathetic neurotransmission and activation of the renin-angiotensin system. We studied the involvement of the caudal ventrolateral medulla in the establishment of this(More)
OBJECTIVE To evaluate the personality characteristics of a group of participants in Phase 1 studies and to study the relation between the personality traits and the adverse events during participation. METHODS Study population consisted of 139 healthy volunteers to Phase 1 studies. Personality was assessed through the Revised NEO Personality Inventory(More)