Antónia Amaral Turkman

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We describe a nonparametric Bayesian approach for estimating the three-way ROC surface based on mixtures of finite Polya trees (MFPT) priors. Mixtures of finite Polya trees are robust models that can handle nonstandard features in the data. We address the difficulties in modeling continuous diagnostic data with skewness, multimodality, or other nonstandard(More)
OBJECTIVE Respiratory function tests are used to detect early signs of hypoventilation in amyotrophic lateral sclerosis (ALS). However, there are few studies of the predictive value of these tests in detecting hypoventilation. METHODS We included 199 ALS patients. ALS was bulbar-onset in 68 and spinal-onset in 131. Twenty-four had hypercapnia (pCO(2)>45(More)
We studied the upper (UMN) and lower motor neuron (LMN) innervations of 159 hands from 81 patients with amyotrophic lateral sclerosis (ALS). Eleven patients with various chronic LMN disorders causing weakness in the abductor digiti minimi (ADM) muscle served as LMN controls. Thirty healthy subjects served as normal controls. Cortical motor threshold,(More)
OBJECTIVE Motor unit recruitment order and firing rate was investigated in healthy subjects, and in small numbers of patients 50years ago. We aimed to investigate firing rate in different disorders, testing the same target muscle with normal strength, to evaluate possible application in diagnosing upper motor neuron (UMN) lesion. METHODS We studied motor(More)
OBJECTIVES We aimed to identify the most appropriate MUP parameter to evaluate reinnervation in very early ALS. METHODS We studied tibialis anterior (TA), initially of normal strength with normal MUP analysis parameters, in 15 patients with ALS of recent onset. They were studied at the initial diagnostic assessment, and then 3 and 6 months later.(More)
Preface Bioinformatics aims at understanding living systems using biological information. We see it as a subset of Computational Biology that deals specifically with the biological problems where knowledge can be gained from the information that we can extract from Biology. These problems arise at all levels and scales of observation, from molecules to(More)
A HPLC-diode array detector (DAD) methodology was developed to allow the simultaneous identification and quantification of Reseda luteola L. (weld) dye flavonoids, luteolin, apigenin, luteolin 7-O-glucoside, apigenin 7-O-glucoside, luteolin 3',7-O-diglucoside and luteolin 4'-O-glucoside. The method was validated with excellent results in linearity,(More)
Supervised and unsupervised selection of genes in microarray data 73 Fatma Haouari and Mohamed Limam Gene expression measures of oligonucleotide microarray technology 85 A new limiting distribution for a statistical test for the homogeneity of two multinomial populations 127 Foreword This volume contains a selection of papers (invited and contributed)(More)
Vegetation burning is a common land management practice in Africa, where fire is used for hunting, livestock husbandry, pest control, food gathering, cropland fertilization, and wildfire prevention. Given such strong anthropogenic control of fire, we tested the hypotheses that fire activity displays weekly cycles, and that the week day with the fewest fires(More)