Anshul Sarvate

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Leprosy or Hansen’s disease is caused by an obligate intracellular pathogen i.e. Mycobacterium leprae. Leprosy is a granulomatous disease of peripheral nerves and mucosa of the upper respiratory tract. This infectious disease results in Leprosy reactions that cause irreversible nerve damage and disabilities. The organism requires minimal set of functional(More)
Gene functions are manifested in the form of proteins. They are central for the various biological activities. For the cell to properly function, proteins must be properly expressed at specific location where they are required and at proper time. Though the proteins are expressed properly, they should acquire a proper stable 3D structure to perform its(More)
In this study, potential inhibitors against Harpin protein (Pectobacterium carotovorum), and Single- stranded DNA binding protein (Pseudomonas aeruginosa) is to be found. Modelled 3-D structure of target protein and their newly designed leads (inhibitors) are used for molecular docking studies using Hex 5.1. For machine learning approach, three data sets of(More)
Plasmodium falciparum, the causative agent of severe human malaria. The dominance of resistant strains has compelled to the discovery and development of new and different modes-ofaction. Current plasmodial drug discovery efforts remains lack far-reaching set of legitimated drug targets. Prerequisite of these targets (or the pathways in which they function)(More)
In this study, 3-D structures of Harpin protein (Pectobacterium carotovorum), Single-stranded DNA binding protein (Pseudomonas aeruginosa), and R2.LlaJI (Campylobacter conisus 13826) has been modelled. For modelling, template selection is done by BLASTp search. For target template alignment, ClustalW server is used and then comparative modelling was done by(More)
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