Learn More
Parallelism pervades all aspects of modern computing, from in-home devices such as cell phones to large-scale supercomputers. Recognizing this - and motivated by the premise that every undergraduate student in a computer-related field should be prepared to cope with parallel computing - a working group sponsored by NSF and IEEE/TCPP, and interacting with(More)
Breast cancer resistance protein (BCRP) is a recently discovered ATP-binding cassette drug transporter. Hence, the full spectrum of therapeutic agents that interact with BCRP remains to be elucidated. Because human immunodeficiency virus protease inhibitors (HPIs) are well known P-glycoprotein (P-gp) substrates, and there is an overlap in substrate(More)
The breast cancer resistance protein (BCRP) plays an important role in drug disposition, including limiting drug penetration across the placental barrier. Our goal was to investigate the effects of pregnancy on Bcrp1 expression in pregnant mice. We examined Bcrp1 expression in placenta, kidney, liver, and small intestine at various gestational ages. Bcrp1(More)
Previous studies have shown that the V12M and Q141K variants of breast cancer resistance protein (BCRP) can affect expression and function of the transporter. In this study, the effects of the I206L, N590Y, and D620N variants on protein expression, plasma membrane localization, and transport activity of BCRP were investigated. Wild-type BCRP and the three(More)
In this paper, we describe a scalable parallel algorithm for sparse matrix factorization, analyze their performance and scalability, and present experimental results for up to 1024 processors on a Cray T3D parallel computer. Through our analysis and experimental results, we demonstrate that our algorithm substantially improves the state of the art in(More)
This paper presents a design flow that optimizes a standard cell based circuit for performance by implementing critical paths in a Programmable Logic Array (PLA). Given a standard-cell based circuit as input, our approach iteratively extracts critical paths from this circuit, which are then implemented using a PLA circuit. PLAs are a good candidate for such(More)